Transferases
A transferase is an enzyme that catalyzes the transfer of a functional group from one molecule to another. As such, protein kinases are a significant member of this family of enzymes, being capable of transferring phosphorus-containing groups (phosphate) from a donor (usually adenosine triphosphate (ATP)) to specific amino acid residues with a free hydroxyl group of an acceptor in a covalent way[1]. As within the class of oxidoreductases, the class of transferases is divided into subclasses, based on the functional groups the enzymes transfer and the substrate specificity.
[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3759 | (aR)-RP-6306 | (aR)-enantiomer of RP-6306 (Axon 3668); PKMYT1 inhibitor | €180.00 | |
| 3743 | (R)-HTS-3 hydrochloride | First potent, selective, and cell-active LPCAT3 inhibitor | €150.00 | |
| 2786 | (±)-PH 797804 | Inhibitor of p38α MAPK | €115.00 | |
| 2537 | 1,5-Isoquinolinediol | PARP1 inhibitor and neuroprotective agent | €50.00 | |
| 1892 | 1-NM-PP1 | Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) | €95.00 | |
| 1496 | 3-Aminobenzamide | Competitive small molecule inhibitor of PARP | €40.00 | |
| 2175 | 3PO | Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. | €65.00 | |
| 1902 | 4μ8C | IRE1α inhibitor | €105.00 | |
| 3476 | 5-NIdR | Potent inhibitor of translesion DNA synthesis (TLS) | €120.00 | |
| 1909 | A 1070722 | Selective inhibitor of GSK-3 | €95.00 | |
| 1831 | A 66 | PI3K inhibitor (p110-α specific) | €95.00 | |
| 1466 | A 769662 | AMPK activator | €85.00 | |
| 1698 | A 770041 | Orally active src-family selective lck inhibitor | €140.00 | |
| 2059 | A 922500 | Highly potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor | €105.00 | |
| 2705 | A-196 | Potent and selective inhibitor of SUV4-20 | €105.00 | |
| 2720 | A-92 | Inhibitor of GCN2 (EIF2AK4) | €145.00 | |
| 2880 | ABC294640 | Selective and orally available SphK2 (or SK2) inhibitor | €125.00 | |
| 2289 | ABT 702 | The first, non-nucleoside adenosine kinase (ADK) inhibitor | €120.00 | |
| 4141 | Acalabrutinib | Orally active, irreversible, and highly selective second-generation BTK inhibitor | Inquire | |
| 2857 | Acalisib | PI3K inhibitor (p110 δ specific) | €120.00 | |
| 3384 | Acyclovir | Highly selective inhibitor of herpes virus DNA polymerase | €60.00 | |
| 1291 | AEG 3482 | JNK inhibitor | €90.00 | |
| 1529 | AG 014699 | PARP1 inhibitor | €60.00 | |
| 1378 | AG 490 | JAK2 inhibitor | €65.00 | |
| 3515 | AG-270 | First-in-class, highly potent, selective, orally bioavailable MAT2A inhibitor | €180.00 | |
| 2389 | AICAR | Potent AMPK activator and inducer of differentiation of NSCs | €45.00 | |
| 2031 | AIM 100 | Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2) | €95.00 | |
| 3408 | AKI603 | Inhibitor of Aurora A kinase | €145.00 | |
| 2540 | Akt Inhibitor VIII | Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) | €95.00 | |
| 2925 | Alpelisib | PI3K inhibitor (p110-α specific) | €90.00 | |