Glycosyltransferases catalyze glycosidic bond formation using sugar donors containing a nucleoside phosphate or a lipid phosphate leaving group. Two structural folds, GT-A and GT-B, have been identified for the nucleotide sugar-dependent enzymes, but other folds are now appearing for the soluble domains of lipid phosphosugar-dependent glycosyl transferases. Donor sugar substrates are most commonly activated in the form of nucleoside diphosphate sugars (e.g., UDP Gal, GDPMan); however, nucleoside monophosphate sugars (e.g., CMP NeuAc), lipid phosphates (e.g., dolichol phosphate oligosaccharides), and unsubstituted phosphate are also used. Nucleotide sugar-dependent glycosyltransferases are often referred to as Leloir enzymes. The acceptor substrates utilized by glycosyltransferases are most commonly other sugars but can also be a lipid, protein, nucleic acid, antibiotic, or another small molecule. Glycosyl transfer most frequently occurs to the nucleophilic oxygen of a hydroxyl substituent of the acceptor. However, it can also occur to nitrogen, sulfur, and carbon nucleophiles[1].

[1] L.L. Lairson et al. Glycosyltransferases: Structures, Functions, and Mechanisms. Ann. Rev. Biochem. 2008, 77, 521-555.

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Axon ID Name Description From price
2537 1,5-Isoquinolinediol PARP1 inhibitor and neuroprotective agent €50.00
1496 3-Aminobenzamide Competitive small molecule inhibitor of PARP €40.00
1529 AG 014699 PARP1 inhibitor €60.00
2241 AZD2461 PARP inhibitor with poor P-glycoprotein substrate qualities €95.00
1847 CP 316819 Glycogen Phosphorylase (GPase) inhibitor €145.00
1268 DR 2313 PARP inhibitor €90.00
3398 E7449 mesylate Potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and TNKS1/2 €110.00
1279 FK 866 NAMPT inhibitor; NAD biosysthesis inhibitor €90.00
1546 FK 866 hydrochloride NAMPT inhibitor €90.00
2885 GeA-69 Selective allosteric and cell-active PARP14 MD2 inhibitor €95.00
1566 Iniparib PARP inhibitor €60.00
2510 IWR-1-endo Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 €90.00
1922 JW 55 Inhibitor of tankyrase (TNKS 1 and 2) €95.00
3557 KPT-9274 Orally bioavailable dual PAK4/NAMPT inhibitor €130.00
4179 KU-0058948 Potent and specific PARP1 inhibitor  Recently added €135.00
2001 KU-0058948 hydrochloride Potent and specific PARP1 inhibitor €135.00
2759 ME0328 PARP3/ARTD3 inhibitor €95.00
3588 NGI-1 Potent and cell-permeable inhibitor of oligosaccharyltransferase €90.00
2928 Niraparib Potent, selective, and orally available PARP1/2 inhibitor €90.00
1370 NU 1025 PARP inhibitor €80.00
2599 NVP-TNKS656 Selective and orally active TNKS inhibitor and antagonist of Wnt pathway activity €95.00
1464 Olaparib PARP inhibitor €50.00
2602 P7C3 Proneurogenic and neuroprotective compound that activates NAMPT €105.00
3795 PDD00017273 First-in-class, selective and cell-active PARG inhibitor €90.00
3113 Rucaparib camsylate PARP1 inhibitor €90.00
3954 SBI-797812 Orally active NAMPT activator €130.00
2253 STF 118804 Highly specific, next-generation NAMPT inhibitor €120.00
2502 Talazoparib Potent, selective, and orally available PARP1/2 inhibitor €90.00
2369 UPF 1069 PARP-2 inhibitor with >26 fold selectivity over PARP1 €75.00
1593 Veliparib PARP inhibitor €40.00

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