PARP

Poly (ADP-ribose) polymerase (PARP; EC 2.4.2.12) is found in the cell’s nucleus. The main role is to detect and signal single strand DNA breaks, preventing healthy cells from malfunctioning and programmed cell death. Cancer cells may also use PARP to repair DNA damage, thus extending their uncontrolled growth. Such cancers can become resistant to treatment (chemotherapy and/or radiation). PARP inhibitors may be especially helpful for the treatment of tumors due to genetic mutations of BRCA1 and BRCA2[1]. Human tankyrases, or TRF1-interacting ankyrin-related ADP-ribose polymerases, are specific PARPs that enhance telomerase access to telomeres, and post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, and trafficking of glut4-containing vesicles[2],[3].


[1] A. Patel, S.H. Kaufmann. Development of PARP Inhibitors: An Unfinished Story. Oncology. 2010, 24, 66-68.
[2] Y.J. Chiang et al. Tankyrase 1 and Tankyrase 2 Are Essential but Redundant for Mouse Embryonic Development. PLoSONE 2008, 3, e2639.
[3] H. Seimiya. The telomeric PARP, tankyrases, as targets for cancer therapy. Br. J. Cancer. 2006, 94, 341-345.

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Axon ID Name Description From price
2537 1,5-Isoquinolinediol PARP1 inhibitor and neuroprotective agent €50.00
1496 3-Aminobenzamide Competitive small molecule inhibitor of PARP €40.00
1593 ABT 888 PARP inhibitor €40.00
2888 ABT 888 dihydrochloride PARP inhibitor €95.00
1529 AG 014699 PARP1 inhibitor €60.00
1464 AZD 2281 PARP inhibitor €50.00
2241 AZD 2461 PARP inhibitor with poor P-glycoprotein substrate qualities €95.00
1268 DR 2313 PARP inhibitor €90.00
3398 E7449 mesylate Potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and TNKS1/2 €110.00
2885 GeA-69 Selective allosteric and cell-active PARP14 MD2 inhibitor €95.00
1566 Iniparib PARP inhibitor €60.00
2001 KU 0058948 hydrochloride Potent and specific PARP1 inhibitor €135.00
2759 ME0328 PARP3/ARTD3 inhibitor €95.00
2928 Niraparib Potent, selective, and orally available PARP1/2 inhibitor €90.00
1370 NU 1025 PARP inhibitor €80.00

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