Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
1575 5-HT6 antagonist 29 Selective brain penetrant 5-HT6 receptor antagonist €90.00
1744 A 77-01 TGF-βR 1 inhibitor; ALK 5 inhibitor €80.00
1421 A 83-01 TGF-βR 1 inhibitor; ALK 5 inhibitor €75.00
2155 A 841720 Non-competitive mGluR1 antagonist €85.00
1990 A 943931 Selective histamine H4 receptor antagonist €75.00
1179 A1B1 hydrochloride CCR1 antagonist €125.00
1419 AB 1010 PDGFR, c-KIT and FGFR3 tyrosine kinase inhibitor €70.00
1510 ABT 239 tartrate H3 antagonist/inverse agonist €135.00
1250 ABT 724 trihydrochloride D4 agonist €85.00
1638 ABT 869 PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor €85.00
1696 AC 220 dihydrochloride FLT3 inhibitor €90.00
1579 ACR 16 hydrochloride Dopaminergic stabilizer that stabilizes psychomotor activity Inquire
1188 Adenosine amine congener Adenosine A1 agonist €125.00
2275 AdipoRon Orally active small-molecule AdipoR agonist €80.00
1751 ADL 5859 Selective δ-opioid receptor agonist €115.00

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