Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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Axon ID Name Description From price
1179 A1B1 hydrochloride CCR1 antagonist €125.00
1648 Ambrisentan Endothelin-A (ETA) antagonist €80.00
1738 AMD 3100 CXCR4 antagonist €85.00
1930 AMD 3465 hexahydrobromide Potent and selective CXCR4 antagonist €85.00
1486 Aprepitant Substance P antagonist (SPA); NK1 inhibitor €125.00
2340 AZ-GHS-22 Orally available Ghrelin receptor (GHS-R1a) inverse agonist €160.00
2255 AZD 8797 Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1) €120.00
2259 BETP Positive allosteric modulator (PAM) at the GLP-1 receptor €105.00
2082 BX 471 Selective CCR1 receptor antagonist €105.00
1901 Casopitant mesylate NK1 antagonist €125.00
2665 Cenicriviroc Oral CCR5-antagonist for treatment of HIV infection  Recently added €145.00
2147 CpdD hydrochloride Ghrelin receptor (GhrR aka GHSR-1a) antagonist €135.00
1800 CXCR3 Antagonist 6c CXCR3 antagonist €145.00
1975 Dilept Neurotensin and dopamine receptor antagonist €120.00
2030 E 5555 hydrobromide Potent and orally active PAR1 antagonist €115.00

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