Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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Axon ID Name Description From price
3435 (S)-VU0637120 First-in-class, selective neuropeptide Y4 receptor allosteric antagonist €120.00
1179 A1B1 hydrochloride CCR1 antagonist €125.00
2898 AC 264613 Potent, selective, and metabolically stable PAR2 agonist €95.00
2388 Adomeglivant Potent, selective, orally administered, and competitive human glucagon receptor (GR) antagonist €95.00
1648 Ambrisentan Endothelin-A (ETA) antagonist €70.00
1738 AMD 3100 CXCR4 antagonist €85.00
1930 AMD 3465 hexahydrobromide Potent and selective CXCR4 antagonist €85.00
1486 Aprepitant Substance P antagonist (SPA); NK1 inhibitor €80.00
3386 AVE0991 Selective and orally active Mas receptor agonist €150.00
2340 AZ-GHS-22 Orally available Ghrelin receptor (GHS-R1a) inverse agonist €160.00
2842 AZD 2098 Potent, selective and bioavailable CCR4 receptor antagonist €125.00
2255 AZD 8797 Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1) €120.00
3363 Azilsartan Potent AT1 antagonist €60.00
2259 BETP Positive allosteric modulator (PAM) at the GLP-1 receptor €105.00
2082 BX 471 Selective CCR1 receptor antagonist €105.00
3104 Candesartan cilexetil Potent and highly specific AT2 receptor antagonist €50.00
1901 Casopitant mesylate NK1 antagonist €125.00
2665 Cenicriviroc Oral CCR5-antagonist for treatment of HIV infection €150.00
2147 CpdD hydrochloride Ghrelin receptor (GhrR aka GHSR-1a) antagonist €135.00
1800 CXCR3 Antagonist 6c CXCR3 antagonist €135.00
2895 D3-βArr Positive allosteric modulator (PAM) of TSH receptor €105.00
1975 Dilept Neurotensin and dopamine receptor antagonist €90.00
2030 E 5555 hydrobromide Potent and orally active PAR1 antagonist €115.00
2012 EMPA Orexin type 2 (OX2) receptor antagonist €135.00
2146 Fedovapagon Selective vasopressin V2 receptor agonist €140.00
3403 Fezolinetant Orally bioavailable NK3 antagonist €140.00
3550 Fimasartan Potent and orally active angiotensin II receptor antagonist €70.00
1607 FK 960 Somatostatin agonist €95.00
3198 FK962 Enhancer of somatostatin release €95.00
1622 GB83 PAR2 antagonist €110.00

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