T 98475
Axon 1270
CAS:
199119-18-1
Purity:
98%
- No solubility data
- MF: C37H37F2N3O4S
- MW: 657.77
Description
Potent and orally active antagonist of Gonadotropin releasing hormone (GnRH), also known as luteinising hormone releasing hormone (LHRH)
More Information
| Parent CAS No. | 199119-18-1 |
|---|---|
| Chemical Name | 3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-isobutyrylamino-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid isopropyl ester |
| SMILES | C1(C(=O)OC(C)C)C(=O)C2C(CN(C)CC3C=CC=CC=3)=C(C3C=CC(NC(=O)C(C)C)=CC=3)SC=2N(CC2C(F)=CC=CC=2F)C=1 |
| MFCD | MFCD09971086 |
| InChi | InChI=1S/C37H37F2N3O4S/c1-22(2)35(44)40-26-16-14-25(15-17-26)34-28(19-41(5)18-24-10-7-6-8-11-24)32-33(43)29(37(45)46-23(3)4)21-42(36(32)47-34)20-27-30(38)12-9-13-31(27)39/h6-17,21-23H,18-20H2,1-5H3,(H,40,44) |
| InChiKey | RANJJVIMTOIWIN-UHFFFAOYSA-N |
| CID | 9874838 |
| Short Description | GnRH antagonist |
References
- Sarma et al. Peptidomimetic GnRH receptor antagonists for the treatment of reproductive and proliferative diseases. Expert Opinon on Ther. Patent. 2006, 16(6), 733-751.
- Cho et al. Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor. J. Med. Chem. 1998, 41, 4190.
