Ion Channels

Ion channels are pore-forming membrane proteins that act as gated pathways for the movement of ions across cell membranes. They are found in both surface and intracellular membranes, and play essential roles in the physiology of all cell types. Ion channels are especially prominent components of the nervous system as they underlie the nerve impulse and because "transmitter-activated" channels mediate conduction across the synapses of a nerve cell’s axon. In addition, ion channels are key components in a wide variety of biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth-muscle contraction, epithelial transport of nutrients and ions, T-cell activation and pancreatic beta-cell insulin release. Many human diseases are caused by defects in ion channel function, which can lead to disease in a number of different ways: Gain, or loss, of channel function (channel-pathies), defective regulation of channel activity by intracellular or extracellular ligands or by channel modulators, by autoantibodies binding to ion channel proteins, or even by ion channels that act as lethal agents[1]. Ion channels can be categorized based upon multiple characteristics, e.g. their selectivity in permeability for a certain type of ion, the number of pores, or by their mechanism of activation.  The wide range of Axon Ligands™  targeting ion channels has been categorized into ligand gated ion channels and voltage gated ion channels (and more). Categories are subdivided on the basis of their selectivity towards activating ligand or the type of ion. In addition, sections are created for specific members of the family of potassium channels that are characterized by their deviant ways of activation (e.g. calcium-activated, and ATP-sensitive potassium channels).


[1] Taken from Oxford Textbook of Medicine, fifth edition, 2010. ISBN 9780470987261.

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Axon ID Name Description From price
1816 A 784168 TRPV1 receptor antagonist €95.00
1915 A 803467 Blocker of the voltage-gated Nav1.8 channel €95.00
2182 A 804598 Potent and selective P2X7 antagonist €125.00
1504 ABT 102 TRPV1 antagonist €90.00
2552 Adjudin Non-hormonal male contraceptive with anti-proliferative activity €125.00
1097 Alosetron hydrochloride 5-HT3 antagonist €85.00
1113 AM 36 dihydrochloride Na+ channel blocker €145.00
2401 AT 1001 High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects €95.00
2243 AVE 0118 hydrochloride Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito), Kir3.4 (IKAch), and IKr currents) €120.00
1096 Azasetron hydrochloride 5-HT3 antagonist €90.00
2534 Azasetron hydrochloride, (+)- 5-HT3 antagonist €135.00
2535 Azasetron hydrochloride, (-)- 5-HT3 antagonist €135.00
1153 B-HT 920 dihydrochloride D2 agonist, α2 adrenoceptor agonist; 5-HT3 antagonist €75.00
1697 BAY K 8644 Ca2+ channel activator (L-type voltage-gated) €95.00
1758 BAY K 8644, (R)-(+)- Ca channel modulator €115.00

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