Ion Channels

Ion channels are pore-forming membrane proteins that act as gated pathways for the movement of ions across cell membranes. They are found in both surface and intracellular membranes, and play essential roles in the physiology of all cell types. Ion channels are especially prominent components of the nervous system as they underlie the nerve impulse and because "transmitter-activated" channels mediate conduction across the synapses of a nerve cell’s axon. In addition, ion channels are key components in a wide variety of biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth-muscle contraction, epithelial transport of nutrients and ions, T-cell activation and pancreatic beta-cell insulin release. Many human diseases are caused by defects in ion channel function, which can lead to disease in a number of different ways: Gain, or loss, of channel function (channel-pathies), defective regulation of channel activity by intracellular or extracellular ligands or by channel modulators, by autoantibodies binding to ion channel proteins, or even by ion channels that act as lethal agents[1]. Ion channels can be categorized based upon multiple characteristics, e.g. their selectivity in permeability for a certain type of ion, the number of pores, or by their mechanism of activation.  The wide range of Axon Ligands™  targeting ion channels has been categorized into ligand gated ion channels and voltage gated ion channels (and more). Categories are subdivided on the basis of their selectivity towards activating ligand or the type of ion. In addition, sections are created for specific members of the family of potassium channels that are characterized by their deviant ways of activation (e.g. calcium-activated, and ATP-sensitive potassium channels).

[1] Taken from Oxford Textbook of Medicine, fifth edition, 2010. ISBN 9780470987261.

17 Item(s)

per page
Axon ID Name Description From price
1309 (R)-(-)-BMS 204352 Potassium channel opener; Less active enantiomer of Axon 1112 €145.00
1759 (S)-(-)-BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) €115.00
1308 (±)-BMS 204352 Potassium channel opener; racemate of Axon 1112 Inquire
1313 1-EBIO K+ channel opener (Ca2+ activated) €50.00
1697 BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) €95.00
1112 BMS 204352 Maxi K+ channel opener €110.00
2724 ICA-069673 KCNQ2/KCNQ3 channel opener; Anti-convulsant €90.00
3091 ICA-110381 KCNQ2/KCNQ3 channel opener; Anti-convulsant €80.00
3516 KCa modulator RA-2 Potent and selective KCa2/3 pan inhibitor €110.00
3490 Minoxidil K+ channel opener (ATP sensitive, vascular) €50.00
2747 ML 213 KCNQ2/KCNQ4 channel opener €75.00
1647 NN 414 K+ channel opener (SUR1/Kir6.2 selective) €110.00
2854 NS 1619 Selective activator of large-conductance Ca2+-activated potassium (BK) channels €95.00
2329 NS 19504 Potent activator of large-conductance Ca2+-activated potassium (BK) channels €90.00
2094 NS 6180 KCa3.1 channel blocker €90.00
1525 Retigabine KCNQ channel opener; Anti-convulsant €90.00
2252 Retigabine dihydrochloride KCNQ channel opener; Anti-convulsant €90.00

17 Item(s)

per page
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