5-HT3 differ from all other 5-HT (serotonin) receptors whose actions are mediated via G proteins. Their structure and function has placed them in the Cys-loop family of cationic ligand-gated ion channels. 5-HT3 receptors are located in both the peripheral (PNS) and central (CNS) nervous systems. In the CNS, 5-HT3 receptors may play roles in a variety of functions including emesis, cognition and anxiety, whereas in the PNS they play a role in a variety of sympathetic, parasympathetic and sensory functions (e.g. signaling in gastrointestinal tract, gut motility and peristalsis).
 5-HT3 Receptors. A. J. Thompson, S. C. R. Lummis. Curr Pharm Des. 2006; 12(28): 3615–3630.
|Axon ID||Name||Description||From price|
|1097||Alosetron hydrochloride||5-HT3 antagonist||€85.00|
|1096||Azasetron hydrochloride||5-HT3 antagonist||€90.00|
|2534||Azasetron hydrochloride, (+)-||5-HT3 antagonist||€135.00|
|2535||Azasetron hydrochloride, (-)-||5-HT3 antagonist||€135.00|
|1153||B-HT 920 dihydrochloride||D2 agonist, α2 adrenoceptor agonist; 5-HT3 antagonist||€75.00|
|1449||Granisetron hydrochloride||5-HT3 antagonist||€85.00|