CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
2694 4BP-TQS Allosteric agonist of α7 nAChR  Recently added €105.00
1575 5-HT6 antagonist 29 Selective brain penetrant 5-HT6 receptor antagonist €90.00
1909 A 1070722 Selective inhibitor of GSK-3 €95.00
1816 A 784168 TRPV1 receptor antagonist €95.00
1915 A 803467 Blocker of the voltage-gated Nav1.8 channel €95.00
2182 A 804598 Potent and selective P2X7 antagonist €125.00
2155 A 841720 Non-competitive mGluR1 antagonist €85.00
1990 A 943931 Selective histamine H4 receptor antagonist €75.00
1504 ABT 102 TRPV1 antagonist €90.00
1510 ABT 239 tartrate H3 antagonist/inverse agonist €135.00
2289 ABT 702 The first, non-nucleoside adenosine kinase (ADK) inhibitor €120.00
1250 ABT 724 trihydrochloride D4 agonist €85.00
1579 ACR 16 hydrochloride Dopaminergic stabilizer that stabilizes psychomotor activity Inquire
1188 Adenosine amine congener Adenosine A1 agonist €125.00
2552 Adjudin Non-hormonal male contraceptive with anti-proliferative activity €125.00

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