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(S)-5-Hydroxy-DPAT hydrobromide
- (S)-5-OH-DPAT
Axon 1008
- Parent CAS: 68643-08-3
- Optical Purity: >98% e.e.
- Soluble in DMSO
- MF: C16H25NO.HBr
- MW: 328.29
Description
Potent and selective dopamine (DA) D2-receptor agonist; more active (S)- enantiomer of 5-OH-DPAT (Axon 1006); its opposite enantiomer, R-5-OH-DPAT (Axon 1007), is a weakly potent D2 antagonist
More Information
| Parent CAS No. | 68643-08-3 |
|---|---|
| Chemical Name | (S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide |
| SMILES | C1C=C2C[C@@H](N(CCC)CCC)CCC2=C(O)C=1.Br |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m0./s1 |
| InChiKey | QHPNEGRNHVBQOB-UQKRIMTDSA-N |
| CID | 90474865 |
| Short Description | D2 agonist |
References
- A. Karlsson et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities. Chirality. 1989-1995, 2(2), 90-95.
- B Shi et al. Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors.Nucl Med Biol. 1999, 26(7), 725-35. (PubMed)
- J Mukherjee et al. In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate.Synapse. 2000, 37(1), 64-70. (PubMed)
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