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(+)-PHNO hydrochloride
- Naxagolide - Dopazinol
Axon 1071
- Parent CAS: 88058-88-2
- Optical Purity: >98% e.e.
- Soluble in water and DMSO
- MF: C15H21NO2.HCl
- MW: 283.79
Description
(+)-PHNO hydrochloride is a very potent and selective dopamine D2 receptor agonist and the more active enantiomer of PHNO (Axon 1070). It is relevant to dopamine receptor agonist studies and to preparation or reference work involving [11C]-(+)-PHNO.
Agonist PET tracers such as [11C]-(+)-PHNO are used to examine dopamine receptor availability and active-state receptor pharmacology. (+)-PHNO hydrochloride is a high-value tool for D2 receptor signaling and neuroimaging-related research.
Key Features
- Very potent dopamine D2 receptor agonist
- More active PHNO enantiomer
- Useful reference for [11C]-(+)-PHNO radiotracer work
- Activates dopamine D2 receptor-mediated signaling
Applications
- D2 receptor pharmacology
- Dopaminergic agonist assays
- PET radiotracer development
- Neuroimaging-related receptor research
More Information
| Parent CAS No. | 88058-88-2 |
|---|---|
| Chemical Name | (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride |
| SMILES | C1(O)=CC2[C@H]3OCCN(CCC)[C@@H]3CCC=2C=C1.Cl |&1:4,12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H21NO2.ClH/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16;/h3,5,10,14-15,17H,2,4,6-9H2,1H3;1H/t14-,15-;/m1./s1 |
| InChiKey | NNEACMQMRLNNIL-CTHHTMFSSA-N |
| CID | 57532 |
| Short Description | D2 agonist |
(+)-PHNO hydrochloride
dopamine D2 receptor agonist
Naxagolide
Dopazinol
PHNO
DRD2
dopamine D2 receptor
D2
Dopamine
Agonist
dopamine signaling
D2 receptor pharmacology
Dopaminergic agonist assays
PET radiotracer development
Neuroimaging-related receptor research
PET imaging
GPCR pharmacology
receptor selectivity
signal transduction
receptor pharmacology
PET
CAS 99705-65-4
CAS 88058-88-2
Axon Medchem
Axon 1071
Supplier
Vendor
References
- Martin et al. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. J. Pharmacol. Exp. Ther. 1985, 233, 2, 395-401.
- N Ginovart et al. Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography. J. Neurochem. 2006, 97, 1089-1103
- P Seeman et al. Dopamine receptors labelled by PHNO. Synapse. 1993, 14(4), 254-62.
- A Graff-Guerrero et al. The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO. Arch Gen Psychiatry. 2009, 66(6), 606-15.
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