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B-HT 958 dihydrochloride
Axon 1337
- Parent CAS: 83718-64-3
Purity:
99%
- Soluble in water
- MF: C14H16ClN3S.2HCl
- MW: 366.74
Description
B-HT 958 dihydrochloride is a dopamine D2 receptor agonist with partial agonist activity at α2-adrenoceptors.
The combined dopaminergic and adrenergic profile of B-HT 958 makes it useful for studying catecholamine receptor cross-talk, presynaptic modulation and CNS neurotransmitter regulation.
Key Features
- Dopamine D2 receptor agonist
- Partial agonist activity at α2-adrenoceptors
- Useful for catecholamine receptor pharmacology
- Relevant to presynaptic modulation and CNS signaling
Applications
- D2 receptor functional assays
- α2-adrenoceptor partial agonist studies
- Catecholamine signaling research
- Dopamine-adrenaline receptor interaction models
More Information
| Parent CAS No. | 83718-64-3 |
|---|---|
| Chemical Name | 6-(4-Chloro-benzyl)-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-ylamine dihydrochloride |
| SMILES | C12N=C(SC=1CCN(CC1C=CC(Cl)=CC=1)CC2)N.Cl.Cl |
| MFCD | MFCD01760396 |
| InChi | InChI=1S/C14H16ClN3S.2ClH/c15-11-3-1-10(2-4-11)9-18-7-5-12-13(6-8-18)19-14(16)17-12;;/h1-4H,5-9H2,(H2,16,17);2*1H |
| InChiKey | GJPGAKKPKZEVGZ-UHFFFAOYSA-N |
| CID | 215696 |
| Short Description | α2 partial & D2 agonist |
B-HT 958 dihydrochloride
dopamine D2 receptor agonist
DRD2
dopamine D2 receptor
D2
Agonist
dopamine signaling
adrenergic signaling
D2 receptor functional assays
α2-adrenoceptor partial agonist studies
Catecholamine signaling research
Dopamine-adrenaline receptor interaction models
GPCR pharmacology
signal transduction
receptor pharmacology
neuroscience
CNS
CAS 83718-64-3
CAS 36085-44-6
Axon Medchem
Axon 1337
Supplier
Vendor
References
- MJ Brown and D Harland. B-HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. Br. J. Pharmacol. 1986, 87(2), 361–370.
- G Cichini et al. B-HT 920 and B-HT 958: Presynaptic effects on electrically evoked 3H-dopamine release from slices of rat nucleus accumbens. Naunyn-Schmiedeberg's Arch. Pharmacol. 1987, 335, 28-31.
- L Pichler et al. B-HT 958, a new α-adrenoceptor agonist with a high pre/postsynaptic activity ratio. Naunyn-Schmiedeberg's Arch. Pharmacol. 1982, 320, 2, 110-114.
- Hörtnagl H et al. B-HT 958--an antagonist at alpha 2-adrenoceptors and an agonist at dopamine autoreceptors in the brain. Eur. J. Pharmacol. 1984, 106(2), 335-344.
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