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(S)-(-)-7-Hydroxy-DPAT hydrochloride

 - (S)-7-OH-DPAT
Axon 1014
  • Parent CAS:  82730-73-2
  • Optical Purity:  98% e.e.
  • Soluble in water and DMSO
  • MF:  C16H25NO.HCl
  • MW:  283.84

Description

(S)-(-)-7-Hydroxy-DPAT hydrochloride is the (S)-enantiomer of 7-Hydroxy-DPAT (Axon 1012) and is described as a dopamine D3 receptor agonist with lower activity than the more active (R)-(+)-7-OH-DPAT enantiomer (Axon 1013). It is useful as a stereochemical comparator in D3 receptor studies.

Enantiomerically defined dopamine ligands help distinguish receptor-mediated activity from stereochemistry-dependent potency and selectivity. (S)-(-)-7-Hydroxy-DPAT hydrochloride can be used alongside racemic or (R)-configured 7-OH-DPAT analogues to assess D3 receptor pharmacology.

Key Features

  • Dopamine D3 receptor agonist
  • Less active enantiomer of 7-OH-DPAT
  • Useful stereochemical comparator
  • Activates dopamine D3 receptor-mediated signaling

Applications

  • D3 receptor pharmacology
  • Enantiomer comparison studies
  • Dopamine receptor subtype assays
  • Structure-activity relationship research

More Information

Parent CAS No. 82730-73-2
Chemical Name (S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrochloride
SMILES C1(O)C=C2C[C@@H](N(CCC)CCC)CCC2=CC=1.Cl |&1:5,r|
MFCD N.A.
InChi InChI=1S/C16H25NO.ClH/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15;/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3;1H/t15-;/m0./s1
InChiKey PMBGJJRWBJWNTG-RSAXXLAASA-N
CID 54582713
Short Description D3 agonist

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