Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information.
 J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
 P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.
|Axon ID||Name||Description||From price|
|2222||10058-F4||c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase||€80.00|
|1992||AS 1517499||Potent and selective STAT6 inhibitor||€145.00|
|2489||Brassinin||Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity||€75.00|
|1863||CID 5951923||Inhibitor of Krüppel-like factor 5 (KLF5)||€135.00|
|1935||DiMNF||Selective aryl hydrocarbon receptor modulator (SAhRM)||€105.00|
|2080||EVP 4593||NF-κB activation inhibitor; inhibits SOC pathway||€110.00|
|2384||FDI 6||Inhibitor of the Forkhead box protein M1 (FOXM1)||€99.00|
|2157||FQI 1||Inhibitor of α-globin transcription factor CP2 (LSF)||€95.00|
|2642||GANT61||Inhibitor of GLI-mediated transcription and Hedgehog (Hh) signaling||Recently added||€120.00|
|2034||HIF-2 inhibitor 2||Allosteric inhibitor of HIF-2||€95.00|
|2614||HIF-2a Translation Inhibitor 76||HIF-2a translation inhibitor that works independent of mTOR||€70.00|
|1890||HSF1A||Human HSF1 activator||€125.00|
|2101||HSF1B||Human HSF1 activator||€125.00|
|2349||JSH 23||Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation||€95.00|
|2378||Kartogenin||Promotor of chondrocyte differentiation from primary human MSCs||€75.00|