Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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Axon ID Name Description From price
2034 HIF-2 inhibitor 2 Allosteric inhibitor of HIF-2 €95.00
2614 HIF-2a Translation Inhibitor 76 HIF-2a translation inhibitor that works independent of mTOR €70.00
1890 HSF1A Human HSF1 activator €125.00
2101 HSF1B Human HSF1 activator €125.00
2349 JSH 23 Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation €95.00
2378 Kartogenin Promotor of chondrocyte differentiation from primary human MSCs €75.00
2538 KRIBB11 HSF1 inhibitor that blocks the induction of HSP27 and HSP70 €125.00
2319 L 002 Inhibitor of p300 HAT (KAT3B) and p53 acetylation €80.00
2480 LW6 Inhibitor of HIF-1α stability via MDH2 inhibition and/or binding with CHP1 €85.00
2733 ML329 Inhibitor of the MITF molecular pathway €105.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €120.00
2671 ML385 Inhibitor of NRF2 €120.00
2517 Napabucasin Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 €105.00
2955 NSC 228155 EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction €75.00
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €95.00

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