Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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Axon ID Name Description From price
2319 L 002 Inhibitor of p300 HAT (KAT3B) and p53 acetylation €80.00
3270 Lj-1-60 Fyn inhibitor targeting the Fyn/Stat3 pathway €90.00
2480 LW6 Inhibitor of HIF-1α stability via MDH2 inhibition and/or binding with CHP1 €85.00
3607 Micheliolide NF-κB activation inhibitor €120.00
2733 ML329 Inhibitor of the MITF molecular pathway €110.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €130.00
2671 ML385 Inhibitor of NRF2 €120.00
3229 MYCi975 MYC inhibitor €110.00
2517 Napabucasin Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 €105.00
3387 NF-κB Activation Inhibitor IV Potent NF-κB activation inhibitor €90.00
3031 NIC3 Inhibitor of nucleus accumbens-associated protein-1 (NAC1) homodimerization €90.00
2955 NSC 228155 EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction €75.00
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €95.00
1402 NSC 348884 NPM inhibitor €120.00
2564 NSC 59984 Activator of p53 that restores WT p53 signaling via p73 activation €95.00
3277 NSC194598 p53 DNA-binding inhibitor €130.00
2651 OAC2 Oct4 and Nanog activating compound that enhances reprogramming efficiency €60.00
2497 Omaveloxolone Triterpenoid activator of NRF2 and inhibitor of NF-κB €90.00
3614 Parthenolide NF-κB activation inhibitor €90.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
3051 Pifithrin-β Inhibitor of p53 protein; Condensation product of Pifithrin-α €95.00
2488 Piperlongumine Natural alkaloid with potent cytotoxic activity €65.00
3480 PY-60 Specific YAP activator targeting ANXA2 €150.00
3520 PY108 Potent, orally bioavailable AHR agonist €120.00
3521 PY109 Potent, orally bioavailable AHR agonist €120.00
3061 RBPJ inhibitor RIN1 First-in-class, potent and selective RBPJ inhibitor €120.00
2313 S3I 201 Potent, cellular STAT3 inhibitor €90.00
2244 SCH 529074 Small molecule activator of mutant p53. €120.00
1701 Shz-1 Stem cell differentiating agent; Nkx2.5 inducer €95.00
2764 SIS3 Potent and selective inhibitor of Smad3 and TGF-βR1 signaling €135.00

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