Transcription Factors
Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].
[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2034 | HIF-2 inhibitor 2 | Allosteric inhibitor of HIF-2 | €95.00 | |
| 2614 | HIF-2a Translation Inhibitor 76 | HIF-2a translation inhibitor that works independent of mTOR | €70.00 | |
| 1890 | HSF1A | Human HSF1 activator | €125.00 | |
| 2101 | HSF1B | Human HSF1 activator | €125.00 | |
| 2349 | JSH 23 | Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation | €95.00 | |
| 2378 | Kartogenin | Promotor of chondrocyte differentiation from primary human MSCs | €75.00 | |
| 2538 | KRIBB11 | HSF1 inhibitor that blocks the induction of HSP27 and HSP70 | €125.00 | |
| 2319 | L 002 | Inhibitor of p300 HAT (KAT3B) and p53 acetylation | €80.00 | |
| 2480 | LW6 | Inhibitor of HIF-1α stability via MDH2 inhibition and/or binding with CHP1 | €85.00 | |
| 2733 | ML329 | Inhibitor of the MITF molecular pathway | €105.00 | |
| 2641 | ML334 | Activator of NRF2 by inhibition of Keap1-NRF2 interactions | €120.00 | |
| 2671 | ML385 | Inhibitor of NRF2 | €120.00 | |
| 2517 | Napabucasin | Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 | €105.00 | |
| 2955 | NSC 228155 | EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction | €75.00 | |
| 2016 | NSC 319726 | Reactivator of the p53 mutant p53R175 | €95.00 | |