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10058-F4
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C12H11NOS2
- MW: 249.35
Description
10058-F4 is a small-molecule c-Myc inhibitor that disrupts or prevents c-Myc-Max heterodimer formation and abrogates c-Myc-dependent functions. It induces dose-dependent G0/G1 cell-cycle arrest and promotes myeloid differentiation in human acute myeloid leukemia models.
MYC is a central oncogenic transcription factor controlling proliferation, metabolism and differentiation. 10058-F4 is relevant for studying MYC dependency and transcription factor inhibition in cancer cells.
Key Features
- Disrupts c-Myc-Max interaction biology
- Inhibits c-Myc-dependent transcriptional functions
- Induces G0/G1 cell-cycle arrest
- Promotes differentiation in AML models
Applications
- MYC pathway research
- Transcription factor inhibitor assays
- Leukemia differentiation studies
- Cancer cell-cycle and proliferation profiling
More Information
| Parent CAS No. | 403811-55-2 |
|---|---|
| Chemical Name | 5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one |
| SMILES | S1/C(=C/C2=CC=C(CC)C=C2)/C(=O)NC1=S |
| MFCD | MFCD04969046 |
| InChi | InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+ |
| InChiKey | SVXDHPADAXBMFB-JXMROGBWSA-N |
| CID | 1271002 |
| Short Description | c-Myc inhibitor |
References
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