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MYCi975
- NUCC-0200975
Axon 3229
CAS:
2289691-01-4
Purity:
99%
- Soluble in DMSO
- MF: C25H16Cl2F6N2O2
- MW: 561.3
Description
MYCi975 (NUCC-0200975) is a MYC inhibitor that disrupts the MYC/MAX interaction while also decreasing MYC protein stability. This dual mechanism of action leads to significant inhibition of MYC-dependent cancer cell proliferation in vitro, suppression of global MYC target gene expression, and inhibition of tumor growth in vivo.
MYC is a master transcription factor that regulates cell growth, metabolism, proliferation, and oncogenic transformation. MYCi975 exhibits an excellent pharmacokinetic profile with a long terminal half-life, high peak plasma concentration, and effective tumor penetration. Pharmacodynamic studies demonstrated increased MYC T58 phosphorylation, and MYCi975 has also been shown to enhance immunotherapy responses.
Key Features
- Dual-action MYC inhibitor
- Disrupts MYC/MAX protein interaction
- Decreases MYC protein stability
- Suppresses MYC target gene expression
- Enhances immunotherapy responses
Applications
- MYC signaling research
- Cancer biology and oncology studies
- Transcription factor biology investigations
- Tumor growth and proliferation research
- Cancer immunotherapy combination studies
More Information
| Parent CAS No. | 2289691-01-4 |
|---|---|
| Chemical Name | 4'-Chloro-6-(4-chlorobenzyloxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3'-(trifluoromethyl)biphenyl-2-ol |
| SMILES | C1C=C(OCC2C=CC(Cl)=CC=2)C(C2C=C(C(F)(F)F)C(Cl)=CC=2)=C(O)C=1C1=CC(C(F)(F)F)=NN1C |
| MFCD | N.A. |
| InChi | InChI=1S/C25H16Cl2F6N2O2/c1-35-19(11-21(34-35)25(31,32)33)16-7-9-20(37-12-13-2-5-15(26)6-3-13)22(23(16)36)14-4-8-18(27)17(10-14)24(28,29)30/h2-11,36H,12H2,1H3 |
| InChiKey | VSDFDVBYONIJLD-UHFFFAOYSA-N |
| CID | 139600320 |
| Short Description | MYC inhibitor |
MYCi975
NUCC-0200975
NUCC 0200975
NUCC0200975
MYC inhibitor
c-MYC inhibitor
MYC/MAX inhibitor
MYC MAX interaction
MYC protein stability
transcription factor inhibitor
c-MYC
MYC signaling
oncogene
cancer cell proliferation
tumor growth
gene expression
MYC target genes
MYC T58 phosphorylation
cancer immunotherapy
DNA-RNA
Transcription Factors
CAS 2289691-01-4
Axon Medchem
Axon 3229
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