Basic Domains

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].
Transcription factors with basic DNA-binding domains include Leucine zipper  (bZIP), Helix-loop-helix (bHLH), hybrid (bHLH-ZIP), NF-1, RF-X and bHSH factors[2].

[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.


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Axon ID Name Description From price
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
1935 DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) €105.00
2034 HIF-2 inhibitor 2 Allosteric inhibitor of HIF-2 €95.00
2614 HIF-2a Translation Inhibitor 76 HIF-2a translation inhibitor that works independent of mTOR €70.00
2480 LW6 Inhibitor of HIF-1α stability via MDH2 inhibition and/or binding with CHP1 €85.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €120.00
2671 ML385 Inhibitor of NRF2  Recently added €120.00
2497 RTA 408 Triterpenoid activator of NRF2 and inhibitor of NF-κB €110.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00

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