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HIF-2a Translation Inhibitor 76
- Soluble in DMSO
- MF: C9H9N3O4S2
- MW: 287.32
Description
HIF-2a Translation Inhibitor 76 (compound 76) is a selective HIF-2a translation inhibitor with IC50 value of 5 µM. It decreases HIF-2α protein and the target gene expression in normoxia and hypoxia. Its unique mechanism works independently of HIF-2α mRNA expression, protein stability, and mTOR activity by enhancing IRP1 binding to the HIF-2α Iron-Responsive Element (IRE).
HIF-2a Translation Inhibitor 76 serves as a vital tool for studying HIF-2α translation, DNA-RNA interactions, and downstream pharmacology across biochemical, cellular, and disease-model assays.
Key Features
- Selective HIF-2a translation inhibitor
- IC50 5 µM
- Decreases HIF-2α protein and target gene expression in normoxia and hypoxia
- Enhances binding of IRP1 to the HIF-2a IRE
Applications
- HIF-2a translation pharmacology and target-validation studies
- HIF-2a translation pathway study or simply remove as feeling duplication
- Disease-relevant cellular and translational model systems
- DNA repair, replication or genome-stability research
More Information
| Parent CAS No. | 882268-69-1 |
|---|---|
| Chemical Name | Methyl 3-(2-(cyano(methylsulfonyl)methylene)hydrazinyl)thiophene-2-carboxylate |
| SMILES | C1(C(OC)=O)SC=CC=1N/N=C(/C#N)S(C)(=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C9H9N3O4S2/c1-16-9(13)8-6(3-4-17-8)11-12-7(5-10)18(2,14)15/h3-4,11H,1-2H3/b12-7- |
| InChiKey | OOGAPDPPVHJYGJ-GHXNOFRVSA-N |
| CID | 5715626 |
| Short Description | HIF-2a translation inhibitor |
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