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IOX2
- Soluble in DMSO
- MF: C19H16N2O5
- MW: 352.34
Description
IOX2 is a selective inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PHD/EGLN), with reported cellular activity and IC50 value of 21 nM for PHD2/EGLN1.
PHD enzymes hydroxylate HIFα subunits to promote oxygen-dependent degradation, thereby controlling hypoxia-responsive transcription. IOX2 is used to stabilize HIF signaling and study oxygen-sensing pathways, angiogenesis and metabolic adaptation.
Key Features
- Selective HIF prolyl hydroxylase inhibitor
- IC50: 21 nM for PHD2/EGLN1
- Does not inhibit FIH at 20 μM in reported assays
- Stabilizes HIF pathway signaling
Applications
- Hypoxia and oxygen-sensing research
- HIF stabilization and transcriptional response assays
- PHD/EGLN enzyme inhibition studies
- Angiogenesis and metabolic adaptation models
More Information
| Parent CAS No. | 931398-72-0 |
|---|---|
| Chemical Name | 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid |
| SMILES | C(O)(=O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O |
| MFCD | MFCD22580424 |
| InChi | InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23) |
| InChiKey | CAOSCCRYLYQBES-UHFFFAOYSA-N |
| CID | 54685215 |
| Short Description | PHD inhibitor |
References
- YM Tian et al. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. J. Biol. Chem. 2011, 286(15), 13041-13051.
- JK Murray et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J. Comb. Chem. 2010, 12(5), 676-686.
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