Oxygenases
Oxygenases (subclass of oxidoreductases; EC 1.) are enzymes that incorporate oxygen atoms from O2 into the oxidized products. Dioxygenases are uncommon enzymes that incorporate both atoms of O2 into one substrate. Besides the large family of cytochrome P450-related (CYP) enzymes, this class of oxidoreductases also includes the well-known family of cyclooxygenases (COX, officially known as prostaglandin-endoperoxide synthase (PTGS))[1], but also histone demethylases (JMJD), desaturases and aromatases, and many others.
[1] Cyclooxygenase enzymes: regulation and function. F.A. Fitzpatrick. Curr. Pharm. Des. 2004, 10, 577-588.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2989 | 15-LOX-1 inhibitor i472 | Inhibitor of 15-lipoxygenase-1 (15-LOX-1) | €170.00 | |
| 1873 | Abiraterone | Inhibitor of CYP17A1 | €90.00 | |
| 1874 | Abiraterone acetate | Prodrug of Abiraterone; Inhibitor of CYP17A1 | €90.00 | |
| 3316 | Anastrozole | Potent, highly selective, and orally active aromatase inhibitor | €50.00 | |
| 2288 | ATB 346 | Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor | €110.00 | |
| 2306 | Bizine | Potent LSD1 inhibitor with selectivity over MAO-A/B, and LSD2 | €120.00 | |
| 3479 | BN80933 | Potent antioxidant and selective nNOS inhibitor | €150.00 | |
| 2489 | Brassinin | Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity | €75.00 | |
| 1919 | Celecoxib | Selective COX-2 inhibitor | €50.00 | |
| 3163 | Clotrimazole | Fungal CYP450 enzyme 14α-demethylase inhibitor | €50.00 | |
| 2622 | CPI 4203 | Selective inhibitor of KDM5 demethylases (H3K4 specific) | €85.00 | |
| 2573 | CPI 455 | Selective inhibitor of KDM5 demethylases (H3K4 specific) | €95.00 | |
| 2494 | D-Luciferin | Natural substrate of firefly luciferase. Compound for bioluminescence imaging (BLI) | €95.00 | |
| 1815 | Delavirdine | NNRT inhibitor (HIV-1) | €90.00 | |
| 3176 | Diethylcarbamazine citrate | Filaricidal drug | €40.00 | |
| 3448 | Diflunisal | COX-inhibitor; NSAID | €50.00 | |
| 3190 | DLCI-1 | Potent and selective inhibitor CYP2A6 inhibitor | €80.00 | |
| 1977 | DMOG | Cell-permeable HIF-PHD inhibitor with pro-angiogenic and -osteogenic properties | €65.00 | |
| 3369 | Efinaconazole | Fungal CYP450 enzyme 14α-demethylase inhibitor | €60.00 | |
| 3674 | Ena21 hydrochloride | Selective and competitive ALKBH5 inhibitor | €110.00 | |
| 3451 | Etodolac | Selective COX-2 inhibitor | €50.00 | |
| 3885 | Etoricoxib | Potent, selective and orally active cyclooxygenase-2 (COX-2) inhibitor | €90.00 | |
| 2045 | Exemestane | Irreversible steroidal aromatase (CYP19A1) inhibitor | €80.00 | |
| 2570 | FG-2216 | Orally active HIF-PHD inhibitor that increases plasma EPO levels in vivo | €80.00 | |
| 2588 | FG-4592 | New-generation oral HIF-PHD inhibitor | €55.00 | |
| 4054 | Fluc inhibitor cpd 48 | Highly potent and reversible Firefly luciferase inhibitor | €120.00 | |
| 2105 | Fluconazole | Fungal CYP450 enzyme 14α-demethylase inhibitor | €60.00 | |
| 3126 | Flurbiprofen | COX-inhibitor; NSAID | €50.00 | |
| 3597 | GNF-PF-3777 | Potent hIDO2 inhibitor | €120.00 | |
| 1934 | GSK J1 | Histone demethylase JMJD3/UTX inhibitor | €105.00 | |