Oxygenases

Oxygenases (subclass of oxidoreductases; EC 1.) are enzymes that incorporate oxygen atoms from O2 into the oxidized products. Dioxygenases are uncommon enzymes that incorporate both atoms of O2 into one substrate. Besides the large family of cytochrome P450-related (CYP) enzymes, this class of oxidoreductases also includes the well-known family of cyclooxygenases (COX, officially known as prostaglandin-endoperoxide synthase (PTGS))[1], but also histone demethylases (JMJD), desaturases and aromatases, and many others.


[1] Cyclooxygenase enzymes: regulation and function. F.A. Fitzpatrick. Curr. Pharm. Des. 2004, 10, 577-588.

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Axon ID Name Description From price
1873 Abiraterone Inhibitor of CYP17A1 €90.00
1874 Abiraterone acetate Prodrug of Abiraterone; Inhibitor of CYP17A1 €90.00
2288 ATB 346 Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor €110.00
2306 Bizine Potent LSD1 inhibitor with selectivity over MAO-A/B, and LSD2 €120.00
2489 Brassinin Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity €75.00
1919 Celecoxib Selective COX-2 inhibitor €50.00
2622 CPI 4203 Selective inhibitor of KDM5 demethylases (H3K4 specific) €85.00
2573 CPI 455 Selective inhibitor of KDM5 demethylases (H3K4 specific) €95.00
1815 Delavirdine NNRT inhibitor (HIV-1) €90.00
1977 DMOG Cell-permeable HIF-PHD inhibitor with pro-angiogenic and -osteogenic properties €65.00
2045 Exemestane Irreversible steroidal aromatase (CYP19A1) inhibitor €90.00
2570 FG-2216 Orally active HIF-PHD inhibitor that increases plasma EPO levels in vivo €95.00
2588 FG-4592 New-generation oral HIF-PHD inhibitor €55.00
2105 Fluconazole Fungal CYP450 enzyme 14α-demethylase inhibitor €60.00
1934 GSK J1 Histone demethylase JMJD3/UTX inhibitor €105.00

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