COX
Cyclooxygenases (officially: prostaglandin G/H synthase, COX; EC 1.14.99.1) catalyze the first two steps in the biosynthesis of prostaglandins (PGs), being the bis-dioxygenation and subsequent reduction of arachidonic acid (AA) to PGG2 and PGH2. The two known isoforms (COX-1 and -2) are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever, inflammation, and tumorigenesis[1]. Due to substrate similarities, inhibitors of this class of enzymes have a lot in common with inhibitors of some desaturase enzymes (e.g. SCD1 and FADS2; EC 1.14.19.1).
[1] Cyclooxygenases: structural and functional insights.C.A. Rouzer, L.J. Marnett. J. Lipid Res. 2009, 50, S29-34.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2288 | ATB 346 | Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor | €110.00 | |
| 1919 | Celecoxib | Selective COX-2 inhibitor | €50.00 | |
| 3176 | Diethylcarbamazine citrate | Filaricidal drug | €40.00 | |
| 3448 | Diflunisal | COX-inhibitor; NSAID | €50.00 | |
| 3451 | Etodolac | Selective COX-2 inhibitor | €50.00 | |
| 3885 | Etoricoxib | Potent, selective and orally active cyclooxygenase-2 (COX-2) inhibitor | €90.00 | |
| 3126 | Flurbiprofen | COX-inhibitor; NSAID | €50.00 | |
| 1974 | GW 406381 | COX-2 inhibitor | €120.00 | |
| 3318 | Indomethacin | COX-inhibitor; NSAID | €50.00 | |
| 3712 | Isoxicam | COX-inhibitor; NSAID | €50.00 | |
| 3364 | Naproxen sodium | COX-inhibitor; NSAID | €40.00 | |
| 3374 | Nepafenac | Prodrug of Amfenac; COX-inhibitor | €50.00 | |
| 3818 | Oxaprozin | COX-inhibitor; NSAID | €80.00 | |
| 3311 | Parecoxib sodium | Prodrug of Valdecoxib; selective COX-2 inhibitor | €50.00 | |
| 1523 | Pravadoline | COX inhibitor; CB agonist | €70.00 | |
| 3376 | Rofecoxib | Orally active COX-2 inhibitor | €60.00 | |
| 2108 | SC 236 | Selective COX-2 inhibitor | €80.00 | |
| 2106 | Valdecoxib | Selective COX-2 inhibitor | €80.00 | |