COX

COX

Cyclooxygenases (officially: prostaglandin G/H synthase, COX; EC 1.14.99.1) catalyze the first two steps in the biosynthesis of prostaglandins (PGs), being the bis-dioxygenation and subsequent reduction of arachidonic acid (AA) to PGG2 and PGH2. The two known isoforms (COX-1 and -2) are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever, inflammation, and tumorigenesis. Due to substrate similarities, inhibitors of this class of enzymes have a lot in common with inhibitors of some desaturase enzymes (e.g. SCD1 and FADS2; EC 1.14.19.1).

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More About COX

Cyclooxygenases (officially: prostaglandin G/H synthase, COX; EC 1.14.99.1) catalyze the first two steps in the biosynthesis of prostaglandins (PGs), being the bis-dioxygenation and subsequent reduction of arachidonic acid (AA) to PGG2 and PGH2. The two known isoforms (COX-1 and -2) are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever, inflammation, and tumorigenesis[1]. Due to substrate similarities, inhibitors of this class of enzymes have a lot in common with inhibitors of some desaturase enzymes (e.g. SCD1 and FADS2; EC 1.14.19.1).

[1] Cyclooxygenases: structural and functional insights.C.A. Rouzer, L.J. Marnett. J. Lipid Res. 2009, 50, S29-34.

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