Cyclooxygenases (officially: prostaglandin G/H synthase, COX; EC catalyze the first two steps in the biosynthesis of prostaglandins (PGs), being the bis-dioxygenation and subsequent reduction of arachidonic acid (AA) to PGG2 and PGH2. The two known isoforms (COX-1 and -2) are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever, inflammation, and tumorigenesis[1]. Due to substrate similarities, inhibitors of this class of enzymes have a lot in common with inhibitors of some desaturase enzymes (e.g. SCD1 and FADS2; EC

[1] Cyclooxygenases: structural and functional insights.C.A. Rouzer, L.J. Marnett. J. Lipid Res. 2009, 50, S29-34.

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Axon ID Name Description From price
2288 ATB 346 Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor €110.00
1919 Celecoxib Selective COX-2 inhibitor €50.00
3176 Diethylcarbamazine citrate Filaricidal drug €40.00
3448 Diflunisal COX-inhibitor; NSAID €50.00
3451 Etodolac Selective COX-2 inhibitor €50.00
3885 Etoricoxib Potent, selective and orally active cyclooxygenase-2 (COX-2) inhibitor €90.00
3126 Flurbiprofen COX-inhibitor; NSAID €50.00
1974 GW 406381 COX-2 inhibitor €120.00
3318 Indomethacin COX-inhibitor; NSAID €50.00
3712 Isoxicam COX-inhibitor; NSAID €50.00
3364 Naproxen sodium COX-inhibitor; NSAID €40.00
3374 Nepafenac Prodrug of Amfenac; COX-inhibitor €50.00
3818 Oxaprozin COX-inhibitor; NSAID €80.00
3311 Parecoxib sodium Prodrug of Valdecoxib; selective COX-2 inhibitor €50.00
1523 Pravadoline COX inhibitor; CB agonist €70.00
3376 Rofecoxib Orally active COX-2 inhibitor €60.00
2108 SC 236 Selective COX-2 inhibitor €80.00
2106 Valdecoxib Selective COX-2 inhibitor €80.00

18 Item(s)

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