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Pravadoline
- WIN 48098
- Soluble in DMSO
- MF: C23H26N2O3
- MW: 378.46
Description
Pravadoline is an analgesic research compound with reported cyclooxygenase inhibitory activity and cannabinoid receptor agonist-like pharmacology.
Pravadoline is pharmacologically relevant for studying the overlap between prostaglandin synthesis, cannabinoid signaling and analgesic responses. It can be used to examine inflammatory pain pathways and receptor-mediated antinociceptive mechanisms.
Key Features
- Cannabimimetic analgesic research compound
- Reported cyclooxygenase inhibitory activity
- Engages cannabinoid-related signaling pathways
- Useful for comparing COX-dependent and cannabinoid-mediated effects
Applications
- Pain and antinociception research
- Inflammation pharmacology
- Cannabinoid receptor signaling studies
- Cyclooxygenase pathway assays
More Information
| Parent CAS No. | 92623-83-1 |
|---|---|
| Chemical Name | (4-Methoxy-phenyl)-[2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone |
| SMILES | C1C=C(OC)C=CC=1C(=O)C1C2C=CC=CC=2N(CCN2CCOCC2)C=1C |
| MFCD | MFCD00864378 |
| InChi | InChI=1S/C23H26N2O3/c1-17-22(23(26)18-7-9-19(27-2)10-8-18)20-5-3-4-6-21(20)25(17)12-11-24-13-15-28-16-14-24/h3-10H,11-16H2,1-2H3 |
| InChiKey | MEUQWHZOUDZXHH-UHFFFAOYSA-N |
| CID | 56463 |
| Short Description | COX inhibitor; CB agonist |
References
- DR Haubrich et al. Pharmacology of pravadoline: a new analgesic agent. J. Pharmacol. Exp. Ther. 1990, 255(2), 511–522.
- TE D'Ambra et al. Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J. Med. Chem. 1992, 35(1), 124–135.
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