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Isoxicam
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C14H13N3O5S
- MW: 335.34
Description
Isoxicam is a nonsteroidal anti-inflammatory drug (NSAID) and a nonselective inhibitor of COX-1 and COX-2.
More Information
| Parent CAS No. | 34552-84-6 |
|---|---|
| Chemical Name | 4-Hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide |
| SMILES | C1C=C2C(O)=C(C(=O)NC3C=C(C)ON=3)N(C)S(=O)(=O)C2=CC=1 |
| MFCD | MFCD00079374 |
| InChi | InChI=1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19) |
| InChiKey | YYUAYBYLJSNDCX-UHFFFAOYSA-N |
| CID | 54677972 |
| Short Description | COX inhibitor |
References
- H Zinnes et al. Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides. Potent nonsteroidal antiinflammatory agents. J Med Chem. 1982 Jan;25(1):12-8.
- S Xu et al Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 2014 Mar 7;289(10):6799-6808.
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