Bulk Inquiry
Rofecoxib
- MK966 - Vioxx
- Soluble in DMSO
- MF: C17H14O4S
- MW: 314.36
Description
Rofecoxib is an orally active cyclooxygenase-2 (COX-2) inhibitor with IC50 values of 26 nM and 18 nM in human osteosarcoma cells and Chinese hamster ovary cells expressing human COX-2, respectively. Rofecoxib exhibits a 1000-fold selectivity for the inhibition of COX-2 compared with the inhibition of COX-1 activity.
More Information
| Parent CAS No. | 162011-90-7 |
|---|---|
| Chemical Name | 4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one |
| SMILES | C1C=C(S(=O)(=O)C)C=CC=1C1COC(=O)C=1C1C=CC=CC=1 |
| MFCD | MFCD00935806 |
| InChi | InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3 |
| InChiKey | RZJQGNCSTQAWON-UHFFFAOYSA-N |
| CID | 5090 |
| Short Description | COX-2 inhibitor |
References
- P Prasit et al. The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1773-8.
- CC Chan et al. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1523 | Pravadoline |
From $77.00 |
| 1919 | Celecoxib |
From $55.00 |
| 1974 | GW 406381 |
From $132.00 |
| 2106 | Valdecoxib |
From $88.00 |
| 2108 | SC 236 |
From $88.00 |
| 2288 | ATB 346 |
From $121.00 |
| 3126 | Flurbiprofen |
From $55.00 |
| 3176 | Diethylcarbamazine citrate |
From $55.00 |
| 3311 | Parecoxib sodium |
From $55.00 |
| 3318 | Indomethacin |
From $55.00 |
| 3374 | Nepafenac |
From $55.00 |
| 3448 | Diflunisal |
From $55.00 |
| 3451 | Etodolac |
From $55.00 |
| 3712 | Isoxicam |
From $55.00 |
| 3818 | Oxaprozin |
From $88.00 |
| 3885 | Etoricoxib |
From $99.00 |
