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GW 406381
- GW 406381X
- Soluble in DMSO
- MF: C21H19N3O3S
- MW: 393.46
Description
GW 406381 is a highly selective cyclooxygenase-2 (COX-2/PTGS2) inhibitor. It suppresses COX-2-mediated prostaglandin production and has been used in models of inflammatory pain and central sensitization.
COX-2 is induced during inflammation and contributes to prostanoid-driven pain, fever and inflammatory signaling. GW 406381 is useful for studying COX-2-selective pharmacology in inflammatory, nociceptive and neuroinflammatory models.
Key Features
- Selective COX-2 inhibitor
- Targets prostaglandin biosynthesis through PTGS2
- Active in inflammatory pain and central sensitization models
- Useful alternative to nonselective cyclooxygenase inhibition
Applications
- COX-2 enzyme pharmacology
- Inflammatory pain studies
- Prostaglandin pathway research
- Central sensitization models
More Information
| Parent CAS No. | 221148-46-5 |
|---|---|
| Chemical Name | 2-(4-ethoxyphenyl)-3-(4-(methylsulfonyl)phenyl)pyrazolo[1,5-b]pyridazine |
| SMILES | C12=C(C3=CC=C(S(C)(=O)=O)C=C3)C(C3=CC=C(OCC)C=C3)=NN1N=CC=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19N3O3S/c1-3-27-17-10-6-16(7-11-17)21-20(19-5-4-14-22-24(19)23-21)15-8-12-18(13-9-15)28(2,25)26/h4-14H,3H2,1-2H3 |
| InChiKey | NXMZBNYLCVTRGB-UHFFFAOYSA-N |
| CID | 9832687 |
| Short Description | COX-2 inhibitor |
References
- S Bingham et al. The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain (...). J. Pharmacol. Exp. Ther. 2005, 312(3), 1161-1169.
- DJ Boswell et al. Evaluation of GW406381 for Treatment of Osteoarthritis of the Knee: Two Randomized, Controlled Studies. Medscape J. Med. 2008, 10(11), 259.
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