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Oxaprozin
- WY21743 - Oxaprozinum
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C18H15NO3
- MW: 293.32
Description
Oxaprozin is an orally active, nonselective COX inhibitor with IC50 values of 2.2 μM and 36 μM for COX-1 and COX-2, respectively. Moreover, Oxaprozin is capable of inhibiting both anandamide hydrolase in neurons (IC50 value of 85 μM), with consequent potent analgesic activity, and NF-κB activation in inflammatory cells (IC50 value of 50 μM).
More Information
| Parent CAS No. | 21256-18-8 |
|---|---|
| Chemical Name | 3-(4,5-Diphenyloxazol-2-yl)propanoic acid |
| SMILES | C1(C2C=CC=CC=2)OC(CCC(O)=O)=NC=1C1C=CC=CC=1 |
| MFCD | MFCD00215977 |
| InChi | InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21) |
| InChiKey | OFPXSFXSNFPTHF-UHFFFAOYSA-N |
| CID | 4614 |
| Short Description | COX inhibitor |
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