Indoleamine 2,3-dioxygenase-1 (IDO1; EC is an enzyme in the eukaryotic tryptophan catabolic pathway. It is a heme-containing, monomeric oxidoreductase that specifically catalyzes the degradation of tryptophan to N-formyl-kynurenine, which can be subsequently metabolized through a series of steps to form nicotinamide adenine dinucleotide (NAD+). IDO1 inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. Previous studies suggest that IDO may be an important regulator of the immunosuppressive mechanisms responsible for tumor escape from host immune surveillance. Several groups have demonstrated that blockade of IDO activity can directly increase the ability of tumor-bearing mice to reject tumors[1].

[1] X. Liu et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 2010, 115, 3520-3530. 

6 Item(s)

per page
Axon ID Name Description From price
2489 Brassinin Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity €75.00
3597 GNF-PF-3777 Potent hIDO2 inhibitor  Recently added €120.00
1733 INCB 024360 Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1) €90.00
2215 INCB 024360-analog Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1) €85.00
3967 LY-3381916 Potent and selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1) Inquire
3325 PF-06840003 Selective, brain penetrant, and orally bioavailable IDO1 inhibitor €70.00

6 Item(s)

per page
Please wait...