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PF-06840003
- EOS200271
Axon 3325
CAS:
198474-05-4
Purity:
98%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C12H9FN2O2
- MW: 232.21
Description
PF-06840003 is a selective, brain penetrant, and orally bioavailable IDO-1 inhibitor. Although PF-06840003 has moderate hIDO1 enzyme inhibition (IC50 value of 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.
More Information
| Parent CAS No. | 198474-05-4 |
|---|---|
| Chemical Name | 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione |
| SMILES | C1(F)C=C2C(C3CC(=O)NC3=O)=CNC2=CC=1 |
| MFCD | MFCD25121820 |
| InChi | InChI=1S/C12H9FN2O2/c13-6-1-2-10-7(3-6)9(5-14-10)8-4-11(16)15-12(8)17/h1-3,5,8,14H,4H2,(H,15,16,17) |
| InChiKey | MXKLDYKORJEOPR-UHFFFAOYSA-N |
| CID | 23063810 |
| Short Description | IDO1 inhibitor |
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