Oxygenases

Oxygenases (subclass of oxidoreductases; EC 1.) are enzymes that incorporate oxygen atoms from O2 into the oxidized products. Dioxygenases are uncommon enzymes that incorporate both atoms of O2 into one substrate. Besides the large family of cytochrome P450-related (CYP) enzymes, this class of oxidoreductases also includes the well-known family of cyclooxygenases (COX, officially known as prostaglandin-endoperoxide synthase (PTGS))[1], but also histone demethylases (JMJD), desaturases and aromatases, and many others.


[1] Cyclooxygenase enzymes: regulation and function. F.A. Fitzpatrick. Curr. Pharm. Des. 2004, 10, 577-588.

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Axon ID Name Description From price
2077 OG-L002 hydrochloride Inhibitor of lysine specific demethylase 1 (LSD1 aka KDM1A) €125.00
2026 PF 04981517 Inhibitor of Cytochrome P450 3A4 (CYP3A4) €110.00
1557 Posaconazole Antifungal agent €95.00
1595 PPP hydrochloride CYP2B6 inhibitor €95.00
1523 Pravadoline COX inhibitor; CB agonist €75.00
2139 RO 61-8048 Inhibitor of kynurenine-3-monooxygenase (KMO) €95.00
2108 SC 236 Selective COX-2 inhibitor €80.00
2864 SP 2509 Potent, reversible, and specific LSD1 inhibitor €90.00
2922 Sulfaphenazole CYP2C9 inhibitor; Antibiotic €60.00
2124 TAK 700 Potent and highly selective inhibitor of 17,20-lyase (CYP17A1) €105.00
2844 ThioLox Inhibitor of 15-lipoxygenase-1 (15-LOX-1) €120.00
1564 Tienilic Acid CYP2C10 Inhibitor €75.00
2628 TMS CYP1B1 inhibitor that induces apoptosis in human cancer cells €75.00
2118 UPF 648 Potent inhibitor of kynurenine-3-monooxygenase (KMO) €115.00
2106 Valdecoxib Selecive COX-2 inhibitor €80.00

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