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DMOG
Axon 1977
CAS:
89464-63-1
Purity:
99%
- Soluble in water and DMSO
- MF: C6H9NO5
- MW: 175.14
Description
Cell-permeable HIF prolyl hydroxylase (PHD) inhibitor that enhances HIF-1α and -2α, vascular endothelial growth factor (VEGF), and platelet-endothelial cell adhesion molecule 1 expression in vitro. Moreover, DMOG combined with butyrate synergistically improved osteoblast differentiation and pro-angiogenic responses. DMOG is also known to delay neuronal cell death caused by trophic factor deprivation, and to ameliorate vasorelaxation after cold ischemia and hypochlorite-induced warm reperfusion injury.
More Information
| Parent CAS No. | 89464-63-1 |
|---|---|
| Chemical Name | methyl 2-(2-methoxy-2-oxoethylamino)-2-oxoacetate |
| SMILES | C(OC)(=O)CNC(C(OC)=O)=O |
| MFCD | MFCD05865098 |
| InChi | InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9) |
| InChiKey | BNJOZDZCRHCODO-UHFFFAOYSA-N |
| CID | 560326 |
| Short Description | PHD inhibitor |
References
- K.M. Woo et al. Synergistic effects of dimethyloxalylglycine and butyrate incorporated into α-calcium sulfate on bone regeneration. Biomaterials. 2015 Jan;39:1-14.
- D.J. Lomb et al. Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J Neurochem. 2007 Dec;103(5):1897-906.
- E. Baader et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 ( Pt 2):525-30.
- T.M. Asikainen et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10212-7.
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