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HIF Phd Inhibitor 4
- Soluble in DMSO
- MF: C21H17ClN4O5S
- MW: 472.9
Description
HIF Phd Inhibitor 4 is an inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PHD/EGLN enzymes). By inhibiting HIF hydroxylation, it promotes stabilization of HIF transcription factors under normoxic experimental conditions.
HIF-PHD enzymes control oxygen-dependent degradation of HIF-1α and HIF-2α, thereby regulating hypoxia-responsive genes involved in angiogenesis, metabolism, erythropoiesis and cell survival. HIF Phd Inhibitor 4 is useful for probing hypoxia signaling and HIF pathway activation.
Key Features
- HIF prolyl hydroxylase inhibitor
- Promotes HIF pathway stabilization
- Targets oxygen-sensing EGLN/PHD biology
- Useful for hypoxia-response pathway research
Applications
- HIF signaling studies
- Hypoxia and angiogenesis research
- Erythropoietic pathway models
- Cell survival and metabolic adaptation assays
More Information
| Parent CAS No. | 1227946-51-1 |
|---|---|
| Chemical Name | N-(4-chlorobenzyl)-3-(5,6-dimethoxypyridin-2-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidine-6-carboxamide |
| SMILES | C1(=O)N(C2=NC(OC)=C(OC)C=C2)C(=O)C2SC(C(NCC3=CC=C(Cl)C=C3)=O)=CC=2N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H17ClN4O5S/c1-30-14-7-8-16(25-19(14)31-2)26-20(28)17-13(24-21(26)29)9-15(32-17)18(27)23-10-11-3-5-12(22)6-4-11/h3-9H,10H2,1-2H3,(H,23,27)(H,24,29) |
| InChiKey | AUGOOTCGUHUYHF-UHFFFAOYSA-N |
| CID | 46203447 |
| Short Description | PHD Inhibitor |
References
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