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Delavirdine
- U 90152 - Rescriptor
- Moderately soluble in DMSO
- MF: C22H28N6O3S
- MW: 456.56
Description
Delavirdine (U-90152) is a non-nucleoside HIV-1 reverse transcriptase inhibitor (NNRTI) that selectively inhibits viral RNA-dependent DNA polymerase activity over host cellular polymerases.
NNRTIs bind an allosteric pocket in HIV-1 reverse transcriptase and suppress viral DNA synthesis. Delavirdine is useful as an antiviral reference compound and for studying reverse transcriptase inhibition, resistance mechanisms and drug-interaction biology.
Key Features
- HIV-1 NNRTI reference compound
- Allosterically inhibits HIV-1 reverse transcriptase
- Selective over host cellular polymerases
- Also relevant to CYP-mediated drug-interaction studies
Applications
- HIV-1 reverse transcriptase inhibition assays
- Antiviral mechanism and resistance research
- NNRTI comparison and profiling studies
- Drug metabolism and CYP interaction assays
More Information
| Parent CAS No. | 136817-59-9 |
|---|---|
| Chemical Name | N-(2-(4-(3-(isopropylamino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)methanesulfonamide |
| SMILES | CS(NC1C=CC2=C(C=1)C=C(C(N1CCN(C3=NC=CC=C3NC(C)C)CC1)=O)N2)(=O)=O |
| MFCD | MFCD00871405 |
| InChi | InChI=1S/C22H28N6O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20/h4-8,13-15,24-26H,9-12H2,1-3H3 |
| InChiKey | WHBIGIKBNXZKFE-UHFFFAOYSA-N |
| CID | 5625 |
| Short Description | NNRT inhibitor |
References
- PJ Pagano and KT Chong. In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha. J Infect Dis. 1995, 171(1), 61-67.
- LJ Scott, CM Perry. Delavirdine: a review of its use in HIV infection. Drugs. 2000, 60(6), 1411-1444.
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