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Remdesivir
- GS-5734
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C27H35N6O8P
- MW: 602.58
Description
Remdesivir is a potent and selective inhibitor of Ebola virus (EBOV) in multiple relevant permissive cell types. Remdesivir inhibits EBOV replication in multiple relevant human cell types including primary macrophages and human endothelial cells with EC50 values of 0.06 to 0.14 μM. The broad-spectrum antiviral activity of Remdesivir in vitro against other pathogenic RNA viruses, including filoviruses, arenaviruses, and coronaviruses, suggests the potential for wider medical use.
More Information
| Parent CAS No. | 1809249-37-3 |
|---|---|
| Chemical Name | (S)-2-Ethylbutyl 2-((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate |
| SMILES | [C@@H]1(O)[C@@H](CO[P@@](N[C@@H](C)C(=O)OCC(CC)CC)(OC2C=CC=CC=2)=O)O[C@@](C#N)(C2N3N=CN=C(N)C3=CC=2)[C@@H]1O |&1:0,2,5,7,27,40,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1 |
| InChiKey | RWWYLEGWBNMMLJ-YSOARWBDSA-N |
| CID | 121304016 |
| Short Description | EBOV inhibitor |
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