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Ganciclovir
- GCV - BIOLF62 - DHPG
- Soluble in 0.1N NaOH(aq), 0.1N HCl(aq) and DMSO
- MF: C9H13N5O4
- MW: 255.23
Description
Ganciclovir is a nucleoside antiviral drug which exhibits in vitro activity against human cytomegalovirus and herpes simplex virus types 1 and 2, and to a lesser degree, Epstein-Barr virus, varicella zoster virus, human herpesvirus 6 and human adenoviruses. The mechanism of action of ganciclovir involves highly selective inhibition of viral DNA replication as a result of enhanced uptake by infected cells, phosphorylation by viral thymidine kinase and/or cellular kinase enzymes, and substrate specificity for viral rather than cellular DNA polymerases.
More Information
| Parent CAS No. | 82410-32-0 |
|---|---|
| Chemical Name | 2-Amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one |
| SMILES | N1C(=O)C2N=CN(COC(CO)CO)C=2N=C1N |
| MFCD | MFCD00870588 |
| InChi | InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) |
| InChiKey | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
| CID | 135398740 |
| Short Description | Polymerase inhibitor |
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