Polymerases

Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs that inhibit the activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses. Three forms of RTIs are known, of which nucleoside- and nucleotide reverse transcriptase inhibitors (NRTIs and NtRTIs respectively) essentially show similar modes of action, while non-nucleoside reverse-transcriptase inhibitors have a completely different mode of action. NNRTIs block reverse transcriptase by binding at a different site on the enzyme, compared to NRTIs and NtRTIs. NNRTIs are not incorporated into the viral DNAbut instead inhibit the movement of protein domains of reverse transcriptase that are needed to carry out the process of DNA synthesis. NNRTIs are therefore classified as non-competitive inhibitors of reverse transcriptase[1].


[1] L.J. Scott, C.M. Perry. Delavirdine: a review of its use in HIV infection. Drugs. 2000, 60, 1411-1444.

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Axon ID Name Description From price
2863 AMI-1 Inhibitor of PRMT €99.00
3008 AOH1160 First-in-class, potent and orally available PCNA inhibitor €120.00
2301 BIBR 1532 Potent and selective telomerase inhibitor inducing senescence in human cancer cells. €70.00
2462 BMH 21 Inhibitor of RNA Polymerase I (RNAP1) €95.00
2173 CX 5461 Inhibitor of RNA Polymerase I (RNAP1) €120.00
1534 Dapivirine NNRT inhibitor €80.00
1815 Delavirdine NNRT inhibitor (HIV-1) €90.00
2855 Dolutegravir HIV integrase inhibitor €135.00
3125 Efavirenz Highly potent, orally bioavailable NNRT inhibitor (HIV-1) €60.00
3239 Entecavir Competitive inhibitor of HBV viral polymerase  Recently added €50.00
3135 Favipiravir Potent and selective inhibitor of viral RNA polymerase €70.00
2208 Gallic acid Multi-affinity drug. Antioxidant. €50.00
3191 Islatravir Potent and long-acting NNRT inhibitor (HIV-1) €220.00
3002 JH-RE-06 Specific and in vivo active REV1-REV7 interaction inhibitor €145.00
3334 Loviride Potent and highly selective NNRT inhibitor (HIV-1)  Recently added €140.00

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