Polymerases
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs that inhibit the activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses. Three forms of RTIs are known, of which nucleoside- and nucleotide reverse transcriptase inhibitors (NRTIs and NtRTIs respectively) essentially show similar modes of action, while non-nucleoside reverse-transcriptase inhibitors have a completely different mode of action. NNRTIs block reverse transcriptase by binding at a different site on the enzyme, compared to NRTIs and NtRTIs. NNRTIs are not incorporated into the viral DNAbut instead inhibit the movement of protein domains of reverse transcriptase that are needed to carry out the process of DNA synthesis. NNRTIs are therefore classified as non-competitive inhibitors of reverse transcriptase[1].
[1] L.J. Scott, C.M. Perry. Delavirdine: a review of its use in HIV infection. Drugs. 2000, 60, 1411-1444.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3476 | 5-NIdR | Potent inhibitor of translesion DNA synthesis (TLS) | €120.00 | |
| 3384 | Acyclovir | Highly selective inhibitor of herpes virus DNA polymerase | €60.00 | |
| 2863 | AMI-1 | Inhibitor of PRMT | €99.00 | |
| 3008 | AOH1160 | First-in-class, potent and orally available PCNA inhibitor | €120.00 | |
| 4030 | AOH1996 | Orally available PCNA inhibitor | Recently added | €140.00 |
| 2301 | BIBR 1532 | Potent and selective telomerase inhibitor inducing senescence in human cancer cells. | €70.00 | |
| 2462 | BMH 21 | Inhibitor of RNA Polymerase I (RNAP1) | €95.00 | |
| 3664 | Brivudine | Inhibitor of herpes virus DNA polymerase | €90.00 | |
| 2173 | CX 5461 | Inhibitor of RNA Polymerase I (RNAP1) | €120.00 | |
| 1534 | Dapivirine | NNRT inhibitor | €80.00 | |
| 1815 | Delavirdine | NNRT inhibitor (HIV-1) | €90.00 | |
| 2855 | Dolutegravir | HIV integrase inhibitor | €135.00 | |
| 3125 | Efavirenz | Highly potent, orally bioavailable NNRT inhibitor (HIV-1) | €60.00 | |
| 3305 | Emtricitabine | Potent and orally bioavailable NRT inhibitor (HIV-1) | €60.00 | |
| 3239 | Entecavir | Competitive inhibitor of HBV viral polymerase | €50.00 | |
| 3135 | Favipiravir | Potent and selective inhibitor of viral RNA polymerase | €70.00 | |
| 2208 | Gallic acid | Multi-affinity drug. Antioxidant. | €50.00 | |
| 3241 | Ganciclovir | Inhibitor of CMV and herpes virus DNA polymerase | €60.00 | |
| 3417 | IMT1B | First-in-class, potent and highly specific allosteric POLRMT inhibitor | €130.00 | |
| 3191 | Islatravir | Potent and long-acting NRT inhibitor (HIV-1) | €140.00 | |
| 3002 | JH-RE-06 | Specific and in vivo active REV1-REV7 interaction inhibitor | €145.00 | |
| 3304 | Lamivudine | Potent NRT inhibitor | €60.00 | |
| 3334 | Loviride | Potent and highly selective NNRT inhibitor (HIV-1) | €140.00 | |
| 3124 | Nevirapine | Potent and selective NNRT inhibitor (HIV-1) | €50.00 | |
| 3385 | Penciclovir | Highly selective inhibitor of herpes virus DNA polymerase | €60.00 | |
| 2965 | PNR-7-02 | Potent inhibitor of human DNA polymerase η | €125.00 | |
| 3120 | Raltegravir | Potent, selective and orally bioavailable HIV integrase inhibitor | €90.00 | |
| 3685 | Rilpivirine | Highly active and orally bioavailable NNRT inhibitor (HIV-1) | €95.00 | |
| 4003 | RP-6685 | Potent, selective, and orally bioavailable Polθ inhibitor | €160.00 | |
| 3301 | Sofosbuvir | Potent and selective HCV NS5B polymerase inhibitor | €90.00 | |