Bulk Inquiry
AMI-1
- AMI-1 sodium salt
- Parent CAS: 134-47-4
- Soluble in water and DMSO
- MF: C21H14N2Na2O9S2
- MW: 548.45
Description
AMI-1 specifically inhibits protein arginine N-methyltransferase (PRMT) activity in vitro (IC50 values of 8.81 and 3.04 µM for PRMT1 and Hmt1p, respectively). Furthermore, AMI-1 prevents in vivo arginine methylation of cellular proteins and can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, thus operating as a brake on certain hormone actions. HIV-1 integrase inhibitor (IC50 value of 4 µM).
More Information
| Parent CAS No. | 134-47-4 |
|---|---|
| Chemical Name | Sodium 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonate) |
| SMILES | C1C(O)=C2C=CC(NC(=O)NC3C=C4C=C(S(O[Na])(=O)=O)C=C(O)C4=CC=3)=CC2=CC=1S(O[Na])(=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2 |
| InChiKey | MOUNHKKCIGVIDI-UHFFFAOYSA-L |
| CID | 121540646 |
| Short Description | PRMT inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2210 | C 7280948 |
From $93.50 |
| 2211 | PRMT3 inhibitor 1 |
From $115.50 |
| 2625 | SGC2085 |
From $132.00 |
| 2709 | CMP5 |
From $104.50 |
| 2710 | HLCL65 hydrochloride |
From $115.50 |
| 2831 | EPZ 015666 |
From $137.50 |
| 3120 | Raltegravir |
From $99.00 |
| 3483 | NBD-556 |
From $77.00 |
| 3681 | MS023 dihydrochloride |
From $99.00 |
| 4344 | ABX464 |
From $132.00 |
