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MS023 dihydrochloride
Axon 3672
- Parent CAS: 1831110-54-3
Purity:
99%
- Soluble in water, DMSO and EtOH
- MF: C17H25N3O.2HCl
- MW: 360.32
Description
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human Type I Protein Arginine Methyltransferases (IC50 values 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively) completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. MS023 potently decreased cellular levels of histone arginine asymmetric dimethylation.
More Information
| Parent CAS No. | 1831110-54-3 |
|---|---|
| Chemical Name | N1-((4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine dihydrochloride |
| SMILES | C1(CN(C)CCN)=CNC=C1C1C=CC(OC(C)C)=CC=1.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C17H25N3O.2ClH/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18;;/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3;2*1H |
| InChiKey | HCNXCUFNZWGILO-UHFFFAOYSA-N |
| CID | 92136227 |
| Short Description | PRMT inhibitor |
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