Bulk Inquiry
PRMT3 inhibitor 1
- Soluble in DMSO
- MF: C15H18N4OS
- MW: 302.39
Description
PRMT3 inhibitor 1 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with reported IC50 of 1.6 µM against full-length PRMT3 in a radioactivity-based assay. It provides a non-competitive approach to modulating PRMT3-dependent arginine methylation.
PRMT3 regulates protein arginine methylation events linked to ribosomal biology, transcription and cellular signaling. PRMT3 inhibitor 1 is relevant for epigenetic methyltransferase research and allosteric inhibitor mechanism studies.
Key Features
- Allosteric PRMT3 inhibitor
- Micromolar potency against full-length PRMT3
- Modulates arginine methyltransferase activity
- Useful tool for non-competitive PRMT inhibition
Applications
- PRMT3 enzymatic assays
- Arginine methylation studies
- Epigenetic inhibitor profiling
- Allosteric methyltransferase mechanism research
More Information
| Parent CAS No. | 1340875-03-7 |
|---|---|
| Chemical Name | 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(2-cyclohexenylethyl)urea |
| SMILES | C12N=NSC1=CC(NC(NCCC1CCCCC=1)=O)=CC=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H18N4OS/c20-15(16-9-8-11-4-2-1-3-5-11)17-12-6-7-13-14(10-12)21-19-18-13/h4,6-7,10H,1-3,5,8-9H2,(H2,16,17,20) |
| InChiKey | GGXCUZHEJUJACD-UHFFFAOYSA-N |
| CID | 53346504 |
| Short Description | PRMT3 inhibitor |
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