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UNC0224
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C26H43N7O2
- MW: 485.67
Description
UNC0224 is a potent and selective G9a histone lysine methyltransferase inhibitor with an IC50 value of 15 nM.
G9a/EHMT2 regulates repressive H3K9 methylation and chromatin-dependent gene silencing. UNC0224 is useful for interrogating epigenetic methyltransferase activity, chromatin regulation and G9a-dependent transcriptional programs.
Key Features
- Potent G9a HMTase inhibitor
- IC50: 15 nM
- Targets histone lysine methylation biology
- Relevant to H3K9 methylation and gene silencing studies
Applications
- G9a/EHMT2 enzyme assays
- Histone methylation and chromatin research
- Epigenetic gene regulation models
- Methyltransferase inhibitor selectivity profiling
More Information
| Parent CAS No. | 1197196-48-7 |
|---|---|
| Chemical Name | 7-(3-(dimethylamino)propoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine |
| SMILES | N1=C2C(C=C(OC)C(OCCCN(C)C)=C2)=C(NC2CCN(C)CC2)N=C1N1CCCN(C)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H43N7O2/c1-30(2)10-7-17-35-24-19-22-21(18-23(24)34-5)25(27-20-8-13-32(4)14-9-20)29-26(28-22)33-12-6-11-31(3)15-16-33/h18-20H,6-17H2,1-5H3,(H,27,28,29) |
| InChiKey | XIVUGRBSBIXXJE-UHFFFAOYSA-N |
| CID | 44251522 |
| Short Description | G9a HMTase inhibitor |
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