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RG 108
- Optical Purity: >98% e.e.
- Soluble in DMSO
- MF: C19H14N2O4
- MW: 334.33
Description
DNA methyltransferase inhibitor; Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity; Demethylates and reactivates epigenetically silenced tumor suppressor genes.
Recently, BIX01294 (Axon 1692) and RG108 have been reported to enhance the efficiency of induced pluripotent stem cell (iPS) generation
*Promotion: RG 108 is also part of Inhibitor Set(s):
| Stem Cell RG-BIX inhibitor Set (Axon 5008) |
More Information
| Parent CAS No. | 48208-26-0 |
|---|---|
| Chemical Name | (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid |
| SMILES | C1=CC2C(C[C@H](N3C(=O)C4=CC=CC=C4C3=O)C(=O)O)=CNC=2C=C1 |&1:5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1 |
| InChiKey | HPTXLHAHLXOAKV-INIZCTEOSA-N |
| CID | 702558 |
| Short Description | DNA MTase inhibitor |
References
- B Brueckner et al. Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases. Cancer Res. 2005, 65, 6305-6311.
- C Stresemann et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 2006, 66(5), 2794-2800.
- Y Shi et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008, 3, 568-574.
- Y Shi et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell. 2008, 2(6), 525-528.
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