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Stem Cell 4i inhibitor Set
- iPSC-TSPC inhibitor Set
Set of 4 Inhibitors
Thiazovivin (Axon 1535)
SB 431542 (Axon 1661)
PD0325901 (Axon 1408)
CHIR99021 (Axon 1386)
(2 mg or 5 mg of each inhibitor)
* Four Inhibitors are in powder form (high purity: 99%)
Ready to be reconstituted freshly to their 10 mM solutions in DMSO respectively.
Expert Recommendation!
Description
A convenient set of four small molecule pathway inhibitors, ROCK inhibitor Thiazovivin (Axon 1535), TGF-β inhibitor SB 431542 (Axon 1661), MEK inhibitor PD 0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386) (termed as stem cell 4i or iPSC-TSPC). The small molecule cocktail of 4 inhibitors (SMC4) was reported to efficiently generate, characterize and maintain single cell and feeder-free (FF) cultural human induced pluripotent stem cells (iPSCs, or hiPSCs), hence a high-throughput reprogramming platform.
Read more: Additional Product Information
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More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | N.A. |
| MFCD | N.A. |
| Short Description | Stem cell inhibitor set |
References
- S.M. Chambers et al. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nature Biotechnol. 2012, 30, 715-720.
- List of publications using PD0325901 (Axon 1408) purchased from Axon Medchem
- List of publications using CHIR99021 (Axon 1386) purchased from Axon Medchem
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