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CCG 232601
- Soluble in DMSO
- MF: C24H20ClF2N3O2
- MW: 455.88
Description
CCG-232601 is an inhibitor of the Rho–MRTF–SRF transcriptional signaling pathway with an IC50 value of 0.55 µM in an SRE.L reporter assay. It suppresses myocardin-related transcription factor-dependent gene expression downstream of Rho-actin dynamics.
CCG-232601 reduces profibrotic transcriptional responses, including expression of smooth-muscle and extracellular-matrix markers. Oral administration inhibited development of bleomycin-induced dermal fibrosis in mice, supporting its use in mechanistic studies of MRTF/SRF signaling and fibrogenesis.
Key Features
- Rho–MRTF–SRF pathway inhibitor
- IC50: 0.55 µM in the SRE.L assay
- Suppresses profibrotic transcription
- Orally bioactive in a dermal-fibrosis model
Applications
- MRTF and SRF signaling research
- Rho-actin transcriptional studies
- Fibroblast activation assays
- Extracellular-matrix research
- Systemic sclerosis and fibrosis models
More Information
| Parent CAS No. | 1922099-21-5 |
|---|---|
| Chemical Name | N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(pyridin-4-yl)benzoyl)piperidine-3-carboxamide |
| SMILES | C1(C2C=CN=CC=2)C=C(C(N2CC(C(NC3C=CC(Cl)=CC=3)=O)CC(F)(F)C2)=O)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H20ClF2N3O2/c25-20-4-6-21(7-5-20)29-22(31)19-13-24(26,27)15-30(14-19)23(32)18-3-1-2-17(12-18)16-8-10-28-11-9-16/h1-12,19H,13-15H2,(H,29,31) |
| InChiKey | MKJLDLGLVZUENS-UHFFFAOYSA-N |
| CID | 121317958 |
| Short Description | Rho/MRTF/SRF inhibitor |
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