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CC-930
- Tanzisertib
Axon 2634
CAS:
899805-25-5
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H23F3N6O2
- MW: 448.44
Description
Potent, selective, and orally active anti-fibrotic JNK inhibitor (IC50 values 61 nM, 7 nM, 6 nM, 480 nM, and 3400 nM for JNK1, JNK2, JNK3, ERK1, and p38α, respectively) for treatment of idiopathic pulmonary fibrosis (IPF).
More Information
| Parent CAS No. | 899805-25-5 |
|---|---|
| Chemical Name | trans-4-(9-((S)-tetrahydrofuran-3-yl)-8-(2,4,6-trifluorophenylamino)-9H-purin-2-ylamino)cyclohexanol |
| SMILES | [C@@H]1(O)CC[C@@H](NC2=NC=C3C(=N2)N([C@H]2CCOC2)C(NC2=C(F)C=C(F)C=C2F)=N3)CC1 |&1:0,4,13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12?,13-,14?/m0/s1 |
| InChiKey | IBGLGMOPHJQDJB-MOKVOYLWSA-N |
| CID | 11597537 |
| Short Description | JNK inhibitor |
References
- VP Krenitsky et al. Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1433-8.
- SA Antoniu. Discontinued drugs for pulmonary, allergy, gastrointestinal, arthritis (2012). Expert Opin Investig Drugs. 2013 Nov;22(11):1453-64.
- N Reich et al. Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis. Ann Rheum Dis. 2012 May;71(5):737-45.
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