Kinases (Serine-Threonine Specific Protein)

The reversible phosphorylation of proteins represents a major post-translational signaling mechanism and regulatory pathway that controls a diverse set of cellular processes. The mode of action of these protein kinases is the reversible hydroxyl-phosphorylation of tyrosine, serine, and/or threonine residues of protein substrates. Since most kinases are specifically targeting tyrosine substrates, or serine/threonine substrates, the Axon Ligands™ in this catalogue targeting kinases have been subdivided into the two corresponding classes.Moreover, often the protein kinase itself is the substrate for an upstream kinase or undergoes auto-phosphorylation as part of a cascade of protein kinase signaling within the cell. Some representative protein kinase signaling pathways within cells include growth factor signaling and stress-activated signaling responses. Such pathways are highly interconnected and complex and regulate numerous cellular functions such as gene transcription, cell growth, proliferation, and differentiation. Signaling pathways of interest that will be highlighted individually are the DNA-damage response, the PI3K/AKT/mTOR pathway, the MAPK/ERK pathway, the NF-κB pathway, the TGF-β pathway, and the Wnt/β-Catenin pathway. Aberrant protein kinase activity can disrupt the normal control of cellular phosphorylation signaling pathways and lead to tumor formation. Given the critical role that protein kinases have in modulating cellular functions such as tumorigenesis, this class of enzymes has been targeted for the discovery and design of biologics and small-molecule inhibitors as potential therapeutic agents[1].


[1] Therapeutic Protein Kinase Inhibitors. S. K. Grant. Cell. Mol. Life Sci. 2009, 66, 1163 – 1177. 

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Axon ID Name Description From price
1902 4μ8C IRE1α inhibitor €105.00
1909 A 1070722 Selective inhibitor of GSK-3 €95.00
1466 A 769662 AMPK activator €85.00
2720 A-92 Inhibitor of GCN2 (EIF2AK4)  Recently added Inquire
1291 AEG 3482 JNK inhibitor €85.00
2389 AICAR Potent AMPK activator and inducer of differentiation of NSCs €45.00
2540 Akt Inhibitor VIII Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) €125.00
1783 AMG 900 Aurora inhibitor (non-specific) €115.00
2611 APS-2-79 Inhibitor of KSR and oncogenic Ras signaling €90.00
2167 AR-A 014418 ATP-competitive GSK-3 inhibitor €85.00
2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor €95.00
2002 AS 602801 JNK inhibitor, which inhibited JNK1, JNK2 and JNK3 €120.00
2179 ASK1 Inhibitor 10 Potent, selective, and orally bioavailable ASK1 inhibitor €125.00
2166 AT 13148 dihydrochloride ATP-competitive inhibitor of multi-AGC kinases €85.00
1539 AT 7519 mesylate CDK inhibitor €85.00

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