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Deguelin
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C23H22O6
- MW: 394.42
Description
More Information
| Parent CAS No. | 522-17-8 |
|---|---|
| Chemical Name | (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H,7aH-pyrano[2,3-c;6,5-f']dichromen-7-one |
| SMILES | C1(OC)C(OC)=CC2[C@]3([H])C(=O)C4C=CC5OC(C)(C)C=CC=5C=4O[C@]3([H])COC=2C=1 |&1:8,25,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1 |
| InChiKey | ORDAZKGHSNRHTD-UXHICEINSA-N |
| CID | 107935 |
| Short Description | AKT inhibitor |
References
- AS Nair et al. Deguelin, an Akt Inhibitor, Suppresses IKBa Kinase Activation Leading to Suppression of NF-KB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion. J. Immunol. 2006, 177, 5612-5622.
- KH Chun et al. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J. Natl. Cancer Inst. 2003, 95, 291-302.
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