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LY 2584702 tosylate
- Parent CAS: 1082949-67-4
- Soluble in DMSO
- MF: C21H19F4N7.C7H8O3S
- MW: 617.62
Description
LY 2584702 tosylate is an orally active, ATP-competitive inhibitor of p70 S6 kinase 1 (S6K1). It blocks mTORC1 downstream signaling through the ribosomal protein S6 axis and shows reported synergy with EGFR and mTOR pathway inhibitors.
S6K1 integrates mTOR signaling with protein synthesis, cell growth and metabolic regulation. LY 2584702 tosylate is useful for studying mTOR/S6K pathway dependency and pathway-combination strategies in oncology models.
Key Features
- Selective p70 S6K1 inhibitor
- Reported IC50: 4 nM for S6K1
- ATP-competitive and orally active pharmacology
- Shows reported synergy with erlotinib and everolimus
Applications
- mTOR/S6K signaling research
- Cancer growth and protein synthesis studies
- Kinase pathway combination assays
- Ribosomal protein S6 phosphorylation analysis
More Information
| Parent CAS No. | 1082949-67-4 |
|---|---|
| Chemical Name | 4-(4-(4-(4-Fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine tosylate |
| SMILES | C1=NC(N2CCC(C3N(C)C=C(C4=CC=C(F)C(C(F)(F)F)=C4)N=3)CC2)=C2C=NNC2=N1.C1(C)C=CC(S(O)(=O)=O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10) |
| InChiKey | HDYUXDNMHBQKAU-UHFFFAOYSA-N |
| CID | 46205871 |
| Short Description | S6K1 inhibitor |
References
- A. Hollebecque et al. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84.
- A. Tolcher et al. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours. Eur J Cancer. 2014 Mar;50(5):867-75.
- H Liu et al. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell Reports 2017 Feb. 18(9):2088–2095.
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