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GSK 690693
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C21H27N7O3
- MW: 425.48
Description
GSK 690693 is a potent ATP-competitive Akt kinase inhibitor with IC50 values of 2 nM for Akt1, 13 nM for Akt2 and 9 nM for Akt3.
Akt isoforms integrate PI3K pathway signaling to control growth, metabolism, survival and apoptosis. GSK 690693 is useful for pan-Akt pathway inhibition and isoform-sensitive kinase pharmacology.
Key Features
- Potent ATP-competitive Akt inhibitor
- IC50: 2 nM for Akt1, 13 nM for Akt2 and 9 nM for Akt3
- Targets all three Akt isoforms
- Useful reference for PI3K/Akt pathway blockade
Applications
- Akt kinase assay development
- PI3K/Akt signaling research
- Cancer cell survival studies
- Isoform and pathway selectivity profiling
More Information
| Parent CAS No. | 937174-76-0 |
|---|---|
| Chemical Name | (S)-4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol |
| SMILES | N1C(C#CC(C)(C)O)=C2N=C(C3C(N)=NON=3)N(CC)C2=C(OC[C@H]2CCCNC2)C=1 |&1:24,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 |
| InChiKey | KGPGFQWBCSZGEL-ZDUSSCGKSA-N |
| CID | 16725726 |
| Short Description | AKT inhibitor |
References
- N Rhodes et al. Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity. Cancer Res. 2008, 68(7), 2366-2374.
- DA Heerding et al. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J. Med. Chem. 2008, 51(18), 5663-5679.
- DS Lew et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood. 2009, 113(8), 1723-1729.
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