Akt/PKB protein kinase (EC 184.108.40.206), also belongs to the cAMP-dependent protein kinase A, -G, and -C (AGC) super family of protein kinases that share structural homology within their catalytic domain and have the similar mechanism of activation. The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. The Akt/PKB family comprises three highly homologous members known as PKBα/Akt1, PKBβ/Akt2 and PKBγ/Akt3 in mammalian cells. The enzyme contributes to activation of a wide variety of cellular processes, including cell survival, growth, proliferation, glucose uptake, metabolism, and angiogenesis. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of diseases, including type-2 diabetes and cancer. As is well known, Akt/PKB also acts a prominent downstream effector of PI3K signaling pathway, and is activated by Class 1A and Class 1B PI3-Kinases.
 The activation of Akt/PKB signaling pathway and cell survival. G. Song, G. Ouyang, S. Bao. J. Cell. Mol. Med. 2005, 9, 59-71.
 AKT/PKB Signaling: Navigating Downstream. B.D. Manning, L.C. Cantley. Cell 2007, 129, 1261-1274.
|Axon ID||Name||Description||From price|
|2540||Akt Inhibitor VIII||Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR)||€125.00|
|2166||AT 13148 dihydrochloride||ATP-competitive inhibitor of multi-AGC kinases||€85.00|
|1859||AZD 5363 dihydrochloride||Inhibitor of protein kinase B (Akt)||€115.00|
|2460||GSK 2110183 hydrochloride||Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases||€105.00|
|1729||GSK 690693||ATP-competitive pan-Akt kinase inhibitor||€115.00|
|1684||MK 2206||Akt inhibitor (allosteric)||€110.00|
|1870||PHT 427||Inhibitor of Akt and PDPK1||€75.00|
|1790||SC 66||Allosteric Akt inhibitor||€70.00|
|2507||SC 79||Unique specific activator of cytosolic Akt; neuroprotective||€75.00|
|1685||YS 49||Antiplatelet, antithrombotic||€135.00|