Akt
Akt/PKB protein kinase (EC 2.7.11.1), also belongs to the cAMP-dependent protein kinase A, -G, and -C (AGC) super family of protein kinases that share structural homology within their catalytic domain and have the similar mechanism of activation[1]. The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. The Akt/PKB family comprises three highly homologous members known as PKBα/Akt1, PKBβ/Akt2 and PKBγ/Akt3 in mammalian cells. The enzyme contributes to activation of a wide variety of cellular processes, including cell survival, growth, proliferation, glucose uptake, metabolism, and angiogenesis[2]. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of diseases, including type-2 diabetes and cancer. As is well known, Akt/PKB also acts a prominent downstream effector of PI3K signaling pathway, and is activated by Class 1A and Class 1B PI3-Kinases.
[1] The activation of Akt/PKB signaling pathway and cell survival. G. Song, G. Ouyang, S. Bao. J. Cell. Mol. Med. 2005, 9, 59-71.
[2] AKT/PKB Signaling: Navigating Downstream. B.D. Manning, L.C. Cantley. Cell 2007, 129, 1261-1274.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2540 | Akt Inhibitor VIII | Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) | €95.00 | |
| 2166 | AT 13148 dihydrochloride | ATP-competitive inhibitor of multi-AGC kinases | €70.00 | |
| 1859 | AZD5363 dihydrochloride | Inhibitor of protein kinase B (Akt) | €90.00 | |
| 4038 | CEP-37440 hydrochloride | Potent, selective and orally active inhibitor of ALK anf FAK | Inquire | |
| 1239 | Deguelin | Akt inhibitor | €95.00 | |
| 4037 | GDC-0068 | Potent, APT-competitive and orally available small molecule pan-Akt inhibitor. | Inquire | |
| 2460 | GSK 2110183 hydrochloride | Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases | €105.00 | |
| 1729 | GSK 690693 | ATP-competitive pan-Akt kinase inhibitor | €130.00 | |
| 3850 | M2698 | p70S6K/Akt dual inhibitor | Inquire | |
| 3268 | Metapristone | Metabolite of Mifepristone (Axon 1502); PI3K/AKT inhibitor | €110.00 | |
| 3247 | Miltefosine | PI3K/Akt inhibitor | €50.00 | |
| 1684 | MK 2206 dihydrochloride | Akt inhibitor (allosteric) | €80.00 | |
| 3343 | ML-9 hydrochloride | MLCK, Akt and STIM1 inhibitor | €60.00 | |
| 1663 | Perifosine | PI3K/Akt inhibitor | €85.00 | |
| 1870 | PHT 427 | Inhibitor of Akt and PDPK1 | €75.00 | |
| 1790 | SC 66 | Allosteric Akt inhibitor | €70.00 | |
| 2507 | SC 79 | Unique specific activator of cytosolic Akt; neuroprotective | €75.00 | |
| 3958 | Uprosertib | Selective and ATP-competitive pan-Akt (PKB) inhibitor | Inquire | |
| 3794 | Urolithin A | Inhibitor of the PI3K/AKT/mTOR pathway | €70.00 | |
| 1685 | YS 49 | Antiplatelet, antithrombotic | €135.00 | |