Akt/PKB protein kinase (EC, also belongs to the cAMP-dependent protein kinase A, -G, and -C (AGC) super family of protein kinases that share structural homology within their catalytic domain and have the similar mechanism of activation[1]. The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli.  The Akt/PKB family comprises three highly homologous members known as PKBα/Akt1, PKBβ/Akt2 and PKBγ/Akt3 in mammalian cells. The enzyme contributes to activation of a wide variety of cellular processes, including cell survival, growth, proliferation, glucose uptake, metabolism, and angiogenesis[2]. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of diseases, including type-2 diabetes and cancer. As is well known, Akt/PKB also acts a prominent downstream effector of PI3K signaling pathway, and is activated by Class 1A and Class 1B PI3-Kinases.

[1] The activation of Akt/PKB signaling pathway and cell survival. G. Song, G. Ouyang, S. Bao. J. Cell. Mol. Med. 2005, 9, 59-71.
[2] AKT/PKB Signaling: Navigating Downstream. B.D. Manning, L.C. Cantley. Cell 2007, 129, 1261-1274.

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Axon ID Name Description From price
2540 Akt Inhibitor VIII Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) €95.00
2166 AT 13148 dihydrochloride ATP-competitive inhibitor of multi-AGC kinases €70.00
1859 AZD5363 dihydrochloride Inhibitor of protein kinase B (Akt) €90.00
4038 CEP-37440 hydrochloride Potent, selective and orally active inhibitor of ALK anf FAK Inquire
1239 Deguelin Akt inhibitor €95.00
4037 GDC-0068 Potent, APT-competitive and orally available small molecule pan-Akt inhibitor. Inquire
2460 GSK 2110183 hydrochloride Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases €105.00
1729 GSK 690693 ATP-competitive pan-Akt kinase inhibitor €130.00
3850 M2698 p70S6K/Akt dual inhibitor Inquire
3268 Metapristone Metabolite of Mifepristone (Axon 1502); PI3K/AKT inhibitor €110.00
3247 Miltefosine PI3K/Akt inhibitor €50.00
1684 MK 2206 dihydrochloride Akt inhibitor (allosteric) €80.00
3343 ML-9 hydrochloride MLCK, Akt and STIM1 inhibitor €60.00
1663 Perifosine PI3K/Akt inhibitor €85.00
1870 PHT 427 Inhibitor of Akt and PDPK1 €75.00
1790 SC 66 Allosteric Akt inhibitor €70.00
2507 SC 79 Unique specific activator of cytosolic Akt; neuroprotective €75.00
3958 Uprosertib Selective and ATP-competitive pan-Akt (PKB) inhibitor Inquire
3794 Urolithin A Inhibitor of the PI3K/AKT/mTOR pathway €70.00
1685 YS 49 Antiplatelet, antithrombotic €135.00

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